A Phase I clinical study of cisplatin-incorporated polymeric micelles (NC-6004) in patients with solid tumours

Plummer, R.; Wilson, R.H.; Calvert, H.; Boddy, A.V.; Griffin, M.; Sludden, J.; Tilby, M.J.; Eatock, M.; Pearson, D.G.; Ottley, C.J.; Matsumura, Y.; Kataoka, K.; Nishiya, T.

doi:10.1038/bjc.2011.6

All Outputs (4)

Early abyssal- and late SSZ-type vestiges of the Rheic oceanic mantle in the Variscan basement of the Sakarya Zone, NE Turkey: Implications for the sense of subduction and opening of the Paleotethys (2011)
Journal Article
Dokuz, A., Uysal, I., Kaliwoda, M., Karsli, O., Ottley, C., & Kandemir, R. (2011). Early abyssal- and late SSZ-type vestiges of the Rheic oceanic mantle in the Variscan basement of the Sakarya Zone, NE Turkey: Implications for the sense of subduction and opening of the Paleotethys. Lithos, 127(1-2), 176-191. https://doi.org/10.1016/j.lithos.2011.08.015

Curcumin ameliorates oxaliplatin-induced chemoresistance in HCT116 colorectal cancer cells in vitro and in vivo. (2011)
Journal Article
Howells, L. M., Sale, S., Sriramareddy, S. N., Irving, G. R., Jones, D. J., Ottley, C. J., …Brown, K. (2011). Curcumin ameliorates oxaliplatin-induced chemoresistance in HCT116 colorectal cancer cells in vitro and in vivo. International Journal of Cancer, 129(2), 476-486. https://doi.org/10.1002/ijc.25670

Therapy-induced carboplatin-DNA adduct levels in human ovarian tumours in relation to assessment of adduct measurement in mouse tissues (2011)
Journal Article
Jarvis, I., Meczes, E., Thomas, H., Edmondson, R., Veal, G., Boddy, A., …Tilby, M. (2012). Therapy-induced carboplatin-DNA adduct levels in human ovarian tumours in relation to assessment of adduct measurement in mouse tissues. Biochemical Pharmacology, 83(1), 69-77. https://doi.org/10.1016/j.bcp.2011.10.005

Despite an increasing understanding of the molecular mechanisms by which platinum drug DNA adducts interact with cellular processes, the relationship between adduct formation in tumours and clinical response remains unclear. We have determined carbop... Read More about Therapy-induced carboplatin-DNA adduct levels in human ovarian tumours in relation to assessment of adduct measurement in mouse tissues.

A Phase I clinical study of cisplatin-incorporated polymeric micelles (NC-6004) in patients with solid tumours (2011)
Journal Article
Plummer, R., Wilson, R., Calvert, H., Boddy, A., Griffin, M., Sludden, J., …Nishiya, T. (2011). A Phase I clinical study of cisplatin-incorporated polymeric micelles (NC-6004) in patients with solid tumours. British Journal of Cancer, 104(4), 593-598. https://doi.org/10.1038/bjc.2011.6

Background: On the basis of preclinical studies of NC-6004, a cisplatin-incorporated micellar formulation, we hypothesised that NC-6004 could show lower toxicity than cisplatin and show greater anti-tumour activity in phase I study. Methods: A total... Read More about A Phase I clinical study of cisplatin-incorporated polymeric micelles (NC-6004) in patients with solid tumours.