To catalyze or not to catalyze? Insight into direct amide bond formation from amines and carboxylic acids under thermal and catalyzed conditions
(2006)
Journal Article
Arnold, K., Davies, B., Giles, R., Grosjean, C., Smith, G., & Whiting, A. (2006). To catalyze or not to catalyze? Insight into direct amide bond formation from amines and carboxylic acids under thermal and catalyzed conditions. Advanced Synthesis & Catalysis, 348(7-8), 813-820. https://doi.org/10.1002/adsc.200606018
Kinetic studies show that the direct formation of amides from amines and carboxylic acids without catalyst does occur under relatively low temperature conditions, but is highly substrate dependent. Boric and boronic acid-based catalysts improve the r... Read More about To catalyze or not to catalyze? Insight into direct amide bond formation from amines and carboxylic acids under thermal and catalyzed conditions.