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To catalyze or not to catalyze? Insight into direct amide bond formation from amines and carboxylic acids under thermal and catalyzed conditions (2006)
Journal Article
Arnold, K., Davies, B., Giles, R., Grosjean, C., Smith, G., & Whiting, A. (2006). To catalyze or not to catalyze? Insight into direct amide bond formation from amines and carboxylic acids under thermal and catalyzed conditions. Advanced Synthesis & Catalysis, 348(7-8), 813-820. https://doi.org/10.1002/adsc.200606018

Kinetic studies show that the direct formation of amides from amines and carboxylic acids without catalyst does occur under relatively low temperature conditions, but is highly substrate dependent. Boric and boronic acid-based catalysts improve the r... Read More about To catalyze or not to catalyze? Insight into direct amide bond formation from amines and carboxylic acids under thermal and catalyzed conditions.

Intercalation and in situ polymerization of poly(alkylene oxide) derivatives within M+-montmorillonite (M = Li, Na, K). (2006)
Journal Article
Greenwell, H., Bowden, A., Chen, B., Boulet, P., Evans, J., Coveney, P., & Whiting, A. (2006). Intercalation and in situ polymerization of poly(alkylene oxide) derivatives within M+-montmorillonite (M = Li, Na, K). Journal of materials chemistry, 16(11), 1082-1094. https://doi.org/10.1039/b505217c

We have synthesized a range of montmorillonite-based clay–polymer nanocomposites by intercalation of a variety of functionalized molecules having poly(ethylene oxide) and poly(propylene oxide) backbones from aqueous solution using a facile batch proc... Read More about Intercalation and in situ polymerization of poly(alkylene oxide) derivatives within M+-montmorillonite (M = Li, Na, K)..

Synthesis and structure of potential Lewis acid-Lewis base bifunctional catalysts: 2-N,N-diisopropylaminophenylboronate derivatives (2005)
Journal Article
Coghlan, S., Giles, R., Howard, J., Patrick, L., Probert, M., Smith, G., & Whiting, A. (2005). Synthesis and structure of potential Lewis acid-Lewis base bifunctional catalysts: 2-N,N-diisopropylaminophenylboronate derivatives. Journal of Organometallic Chemistry, 690(21-22), 4784-4793

Directed ortho-metallation is used to introduce a boron function into N,N-diisopropylbenzamide,. resulting in the formation of both borinate and boronate derivatives. N,N-Diisopropylbenzamide ortho-boronate pinacol ester can be reduced with sodium bo... Read More about Synthesis and structure of potential Lewis acid-Lewis base bifunctional catalysts: 2-N,N-diisopropylaminophenylboronate derivatives.

An insight into the mechanism of the cellulose dyeing process, part 2: Simulation of aggregation, solvent and additive effects upon azo-linked aromatics and dyes (2005)
Journal Article
Hamlin, J., & Whiting, A. (2005). An insight into the mechanism of the cellulose dyeing process, part 2: Simulation of aggregation, solvent and additive effects upon azo-linked aromatics and dyes. Molecular Simulation, 31(8), 605-612

In order to probe the complex process of dying cellulosic materials with common azo- linked dye systems, the aggregation-disaggregation process has been studied using molecular simulation techniques. In particular, the dynamics of multiple dye specie... Read More about An insight into the mechanism of the cellulose dyeing process, part 2: Simulation of aggregation, solvent and additive effects upon azo-linked aromatics and dyes.

Morphology and elastic modulus of novel poly oligo(ethylene glycol) diacrylate -montmorillonite nanocomposites (2005)
Journal Article
Chen, B., Bowden, A., Greenwell, H., Boulet, P., Coveney, P., Whiting, A., & Evans, J. (2005). Morphology and elastic modulus of novel poly oligo(ethylene glycol) diacrylate -montmorillonite nanocomposites. Journal of Polymer Science Part B: Polymer Physics, 43(14), 1785-1793

Novel thermosetting poly[-oligo(ethylene glycol) diacrylate]-sodium montmorillonite nanocomposites containing a range of clay volume fractions were prepared by an in situ polymerization method. X-ray diffraction showed that the basal plane spacing of... Read More about Morphology and elastic modulus of novel poly oligo(ethylene glycol) diacrylate -montmorillonite nanocomposites.

Interlayer structure and bonding in nonswelling primary amine intercalated clays (2005)
Journal Article
Greenwell, H., Harvey, M., Boulet, P., Bowden, A., Coveney, P., & Whiting, A. (2005). Interlayer structure and bonding in nonswelling primary amine intercalated clays. Macromolecules, 38(14), 6189-6200. https://doi.org/10.1021/ma0503817

Preparation of industrially useful clay-polymer nanocomposite materials often requires the dispersal of clay particles within a polymer matrix. The degree to which the clay particles may be dispersed has an effect on the resultant properties of the m... Read More about Interlayer structure and bonding in nonswelling primary amine intercalated clays.

A stereoselective synthesis of 1,6-diphenyl-1,3,5-hexatrienes utilising 4,4,6-trimethyl-2-vinyl-1,3,2-dioxaborinane as a two-carbon alkenyl building block (2005)
Journal Article
Lightfoot, A., Twiddle, S., & Whiting, A. (2005). A stereoselective synthesis of 1,6-diphenyl-1,3,5-hexatrienes utilising 4,4,6-trimethyl-2-vinyl-1,3,2-dioxaborinane as a two-carbon alkenyl building block. Organic and Biomolecular Chemistry, 3(17), 3167-3172. https://doi.org/10.1039/b507900d

A number of 1,6-diphenyl-1,3,5-hexatrienes of varying alkene geometries were stereoselectively prepared from just two starting materials: iodobenzene and 4,4,6-trimethyl-2-vinyl-1,3,2-dioxaborinane via a series of Heck, Suzuki-Miyaura and stereocontr... Read More about A stereoselective synthesis of 1,6-diphenyl-1,3,5-hexatrienes utilising 4,4,6-trimethyl-2-vinyl-1,3,2-dioxaborinane as a two-carbon alkenyl building block.

Absolute stereochemistry assignment of N-phosphorylimine-derived aza-Diels-Alder adducts with TDDFF CD calculations (2005)
Journal Article
Di Bari, L., Guillarme, S., Hermitage, S., Jay, D., Pescitelli, G., & Whiting, A. (2005). Absolute stereochemistry assignment of N-phosphorylimine-derived aza-Diels-Alder adducts with TDDFF CD calculations. Chirality, 17(6), 323-331

N-Phosphorylimines undergo Lewis acid-catalyzed Diels-Alder reactions with Danishefsky's diene. Application of the chiral catalyst zinc (II)- (S)-BINOL results in good-to-low asymmetric induction but poor chemical conversion. However, the absolute st... Read More about Absolute stereochemistry assignment of N-phosphorylimine-derived aza-Diels-Alder adducts with TDDFF CD calculations.

Stereoselective chloro-deboronation reactions induced by substituted pyridine-iodine chloride complexes (2005)
Journal Article
Batsanov, A., Howard, J., Lightfoot, A., Twiddle, S., & Whiting, A. (2005). Stereoselective chloro-deboronation reactions induced by substituted pyridine-iodine chloride complexes. European Journal of Organic Chemistry, 1876-1883

A novel class of charge-transfer complexes based on iodine chloride and substituted pyridines, which possess a number of interesting and unique structural features, can be employed to bring about a stereocontrolled chloro-deboronation of certain viny... Read More about Stereoselective chloro-deboronation reactions induced by substituted pyridine-iodine chloride complexes.

4,4,6-trimethyl-2-vinyl-1,3,2-dioxaborinane: An efficient and selective 2-carbon building block for vinylboronate Suzuki-Miyaura coupling reactions (2005)
Journal Article
Lightfoot, A., Twiddle, S., & Whiting, A. (2005). 4,4,6-trimethyl-2-vinyl-1,3,2-dioxaborinane: An efficient and selective 2-carbon building block for vinylboronate Suzuki-Miyaura coupling reactions. Synlett: Accounts and Rapid Communications in Synthetic Organic Chemistry, 529-531

An extremely simple and efficient palladium-catalyzed coupling procedure for the synthesis of functionalized styrenes and dienes is utilized to demonstrate how 4,4,6-trimethyl-2-vinyl-1,3,2-dioxaborinane can be employed to selectively undergo Suzuki-... Read More about 4,4,6-trimethyl-2-vinyl-1,3,2-dioxaborinane: An efficient and selective 2-carbon building block for vinylboronate Suzuki-Miyaura coupling reactions.

On the mechanism and origin of the stereoselectivity in iodo-deboronation and chloro-deboronation of hindered alkenyl boronate esters using either ICI-NaOMe or ICI-pyridine (2004)
Journal Article
Lightfoot, A., Twiddle, S., & Whiting, A. (2004). On the mechanism and origin of the stereoselectivity in iodo-deboronation and chloro-deboronation of hindered alkenyl boronate esters using either ICI-NaOMe or ICI-pyridine. Tetrahedron Letters, 45(46), 8557-8561

Conversion of hindered alkenyl boronate esters into the corresponding iodoalkene, or alkenyl chloride can be carried out stereoselectively using ICl. In the presence of NaOMe, direct reaction of ICl is favoured yielding the E-iodoalkene, however, the... Read More about On the mechanism and origin of the stereoselectivity in iodo-deboronation and chloro-deboronation of hindered alkenyl boronate esters using either ICI-NaOMe or ICI-pyridine.

Mechanistic studies on the formal aza-Diels-Alder reactions of N-aryl imines: evidence for the non-concertedness under Lewis-acid catalysed conditions (2004)
Journal Article
Hermitage, S., Howard, J., Jay, D., Pritchard, R., Probert, M., & Whiting, A. (2004). Mechanistic studies on the formal aza-Diels-Alder reactions of N-aryl imines: evidence for the non-concertedness under Lewis-acid catalysed conditions. Organic and Biomolecular Chemistry, 2(17), 2451-2460. https://doi.org/10.1039/b407293f

The reaction of a para-methoxyaniline, ethyl glyoxalate-derived imine with a series of dienes has resulted in products, which initially suggest the operation of different modes of aza-Diels-Alder reaction. However, a more likely explanation is that a... Read More about Mechanistic studies on the formal aza-Diels-Alder reactions of N-aryl imines: evidence for the non-concertedness under Lewis-acid catalysed conditions.

Preparation of an advanced phenylglycine-derived intermediate en route to the southern hemisphere tetraene of viridenomycin (2004)
Journal Article
Maw, G., Thirsk, C., Toujas, J., Vaultier, M., & Whiting, A. (2004). Preparation of an advanced phenylglycine-derived intermediate en route to the southern hemisphere tetraene of viridenomycin. Synlett: Accounts and Rapid Communications in Synthetic Organic Chemistry, 1183-1186

A high-yielding synthesis of a phenylglycine derived (E,Z)-dienylboronate en route to the C16-C23 tetraene of the polyene macrolide viridenomycin is described. Crucial to this synthesis was the development of conditions enabling ready access to synth... Read More about Preparation of an advanced phenylglycine-derived intermediate en route to the southern hemisphere tetraene of viridenomycin.

Unexpected temperature, time and solvent effects in the catalytic asymmetric aza-Diels-Alder reaction of an ethyl glyoxylate-derived N-aryl imine with Danishefsky's diene catalysed by a BINOL-zinc complex (2004)
Journal Article
Guillarme, S., & Whiting, A. (2004). Unexpected temperature, time and solvent effects in the catalytic asymmetric aza-Diels-Alder reaction of an ethyl glyoxylate-derived N-aryl imine with Danishefsky's diene catalysed by a BINOL-zinc complex. Synlett: Accounts and Rapid Communications in Synthetic Organic Chemistry, 711-713

The catalytic asymmetric aza-Diels-Alder reaction of an ethyl glyoxylate-derived N-aryl imine with Danishefsky's diene using a BINOL-zinc complex provides the corresponding cycloadduct with moderate to high enantioselectivity, depending on the solven... Read More about Unexpected temperature, time and solvent effects in the catalytic asymmetric aza-Diels-Alder reaction of an ethyl glyoxylate-derived N-aryl imine with Danishefsky's diene catalysed by a BINOL-zinc complex.

Lewis acid-catalysed aza-Diels-Alder versus Mannich reactions of N-diethyl phosphoryl imino dienophiles with oxygenated dienes and application of a chiral lewis acid (2004)
Journal Article
Di Bari, L., Guillarme, S., Hermitage, S., Howard, J., Jay, D., Pescitelli, G., …Yufit, D. (2004). Lewis acid-catalysed aza-Diels-Alder versus Mannich reactions of N-diethyl phosphoryl imino dienophiles with oxygenated dienes and application of a chiral lewis acid. Synlett: Accounts and Rapid Communications in Synthetic Organic Chemistry, 708-710

N-Phosphoryl imines react with oxygenated dienes in the presence of Lewis acids to provide either the formal aza-Diels-Alder adduct, or the acyclic Mannich-type addition product, depending upon the catalyst and work up used, which is in agreement wit... Read More about Lewis acid-catalysed aza-Diels-Alder versus Mannich reactions of N-diethyl phosphoryl imino dienophiles with oxygenated dienes and application of a chiral lewis acid.

Combined experimental and theoretical investigations of clay polymer nanocomposites: intercalation of single bifunctional organic compounds in Na+-montmorillonite and Na+-hectorite clays for the design of new materials (2003)
Journal Article
Boulet, P., Bowden, A., Coveney, P., & Whiting, A. (2003). Combined experimental and theoretical investigations of clay polymer nanocomposites: intercalation of single bifunctional organic compounds in Na+-montmorillonite and Na+-hectorite clays for the design of new materials. Journal of materials chemistry, 13(10), 2540-2550

This paper reports a study of the intercalation of single bifunctional poly(ethylene oxide)- and poly(propylene oxide)- based compounds, with and without modified end groups, in Na+-montmorillonite and Na+-hectorite clays as the starting point for th... Read More about Combined experimental and theoretical investigations of clay polymer nanocomposites: intercalation of single bifunctional organic compounds in Na+-montmorillonite and Na+-hectorite clays for the design of new materials.

Synthesis of C-2-symmetric aza- and azaoxa-macrocyclic ligands derived from (1R,2R)-1,2-diaminocyclohexane and their applications in catalysis (2003)
Journal Article
Pulacchini, S., Sibbons, K., Shastri, K., Motevalli, M., Watkinson, M., Wan, H., …Lightfoot, A. (2003). Synthesis of C-2-symmetric aza- and azaoxa-macrocyclic ligands derived from (1R,2R)-1,2-diaminocyclohexane and their applications in catalysis. Dalton Transactions, 2043-2052

Investigations have been undertaken into the synthesis of chiral derivatives of 1,4,7-triazacyclononane and 1,7-diaza-4-oxacyclononane that incorporate the C-2-symmetric (R,R)-1,2-diaminocyclohexane backbone. The target ligands 17a and 17b have been... Read More about Synthesis of C-2-symmetric aza- and azaoxa-macrocyclic ligands derived from (1R,2R)-1,2-diaminocyclohexane and their applications in catalysis.