Novel transformation of α,β-unsaturated aldehydes and ketones to γ-amino alcohols or 1,3-oxazines via a 4 or 5 step, one-pot sequence
(2012)
Journal Article
Calow;, A., Solé;, C., Fernandez;, E., & Whiting;, A. (2012). Novel transformation of α,β-unsaturated aldehydes and ketones to γ-amino alcohols or 1,3-oxazines via a 4 or 5 step, one-pot sequence. Chemical Communications, 48(93), https://doi.org/10.1039/c2cc36129a
All Outputs (117)
An efficient enantioselective (R)-homoboroproline from (S)-proline using borylation approach (2012)
Journal Article
Georgiou;, I., & Whiting;, A. (2012). An efficient enantioselective (R)-homoboroproline from (S)-proline using borylation approach. European Journal of Organic Chemistry, 2012(22), 4110-4113. https://doi.org/10.1002/ejoc.201200652
Mechanism and optimisation of the homoboroproline bifunctional catalytic asymmetric aldol reaction: Lewis acid tuning through in situ esterification (2012)
Journal Article
Georgiou, I., & Whiting, A. (2012). Mechanism and optimisation of the homoboroproline bifunctional catalytic asymmetric aldol reaction: Lewis acid tuning through in situ esterification. Organic and Biomolecular Chemistry, 10(12), 2422-2430. https://doi.org/10.1039/c2ob06872aThe use of homoboroproline as a bifunctional catalyst in the asymmetric aldol reaction has been investigated mechanistically, particularly with respect to tuning the Lewis acidity of boron by in situ esterification with mildly sigma-electron withdraw... Read More about Mechanism and optimisation of the homoboroproline bifunctional catalytic asymmetric aldol reaction: Lewis acid tuning through in situ esterification.
Catalytic 1,3-difunctionalization of organic backbones via a highly stereoselective, one-pot, boron conjugate-addition/reduction/oxidation process, (2011)
Journal Article
Solé;, C., Tatla;, A., Mata;, J., Whiting;, A., Gulyás;, H., & Fernandez;, E. (2011). Catalytic 1,3-difunctionalization of organic backbones via a highly stereoselective, one-pot, boron conjugate-addition/reduction/oxidation process,. Chemistry - A European Journal, 17(50), https://doi.org/10.1002/chem.201102081
Studies towards the synthesis of the northern polyene of viridenomycin and synthesis of Z-double bond analogues (2011)
Journal Article
Knowles;, J., O’Connor;, V., & Whiting;, A. (2011). Studies towards the synthesis of the northern polyene of viridenomycin and synthesis of Z-double bond analogues. Organic and Biomolecular Chemistry, 9(6), 1876-1886. https://doi.org/10.1039/c0ob00977f
Highly Enantio- and Diastereoselective Synthesis of γ-Amino Alcohols from α,β-Unsaturated Imines through a One-Pot β-Boration/Reduction/Oxidation Sequence (2011)
Journal Article
Solé, C., Whiting, A., Gulyás, H., & Fernández, E. (2011). Highly Enantio- and Diastereoselective Synthesis of γ-Amino Alcohols from α,β-Unsaturated Imines through a One-Pot β-Boration/Reduction/Oxidation Sequence. Advanced Synthesis & Catalysis, 353(2-3), 376-384. https://doi.org/10.1002/adsc.201000842
Copper(II)-Catalyzed Room Temperature Aerobic Oxidation of Hydroxamic Acids and Hydrazides to Acyl-Nitroso and Azo Intermediates, and Their Diels_Alder Trapping (2011)
Journal Article
and Hydrazides to Acyl-Nitroso and Azo Intermediates, and Their Diels_Alder Trapping. Organic Letters, 13(13), 3442-3445. https://doi.org/10.1021/ol201188d
The Uncatalyzed Direct Amide Formation Reaction – Mechanism Studies and the Key Role of Carboxylic Acid H-Bonding (2011)
Journal Article
Charville, H., Jackson, D., Hodges, G., Whiting, A., & Wilson, M. (2011). The Uncatalyzed Direct Amide Formation Reaction – Mechanism Studies and the Key Role of Carboxylic Acid H-Bonding. European Journal of Organic Chemistry, 2011(30), 5981-5990. https://doi.org/10.1002/ejoc.201100714
The first example of enamine–Lewis acid cooperative bifunctional catalysis: application to the asymmetric Aldol reaction (2008)
Journal Article
Arnold, K., Batsanov, A., Davies, B., Grosjean, C., Schütz, T., Whiting, A., & Zawatzkya, K. (2008). The first example of enamine–Lewis acid cooperative bifunctional catalysis: application to the asymmetric Aldol reaction. Chemical Communications, 3879-3881. https://doi.org/10.1039/b806779a
Asymmetric Direct Amide Synthesis by Kinetic Amine Resolution: A Chiral Bifunctional Aminoboronic Acid Catalyzed Reaction between a Racemic Amine and an Achiral Carboxylic Acid. (2008)
Journal Article
Arnold, K., Davies, B., Hérault, D., & Whiting, A. (2008). Asymmetric Direct Amide Synthesis by Kinetic Amine Resolution: A Chiral Bifunctional Aminoboronic Acid Catalyzed Reaction between a Racemic Amine and an Achiral Carboxylic Acid. Angewandte Chemie International Edition, 47(14), 2673-2676. https://doi.org/10.1002/anie.200705643
A catalytic aldol reaction and condensation through in situ boron "ate"-complex enolate generation in water (2008)
Journal Article
Aelvoet, K., Batsanov, A., Blatch, A., Grosjean, C., Patrick, L., Smethurst, C., & Whiting, A. (2008). A catalytic aldol reaction and condensation through in situ boron "ate"-complex enolate generation in water. Angewandte Chemie International Edition, 47(4), 768-770. https://doi.org/10.1002/anie.200704293
Benzimidazole nitrogen-directed, regiocontrolled, lithiation of ferrocenyl- and phenyl-N-n-butylbenzimidazoles (2007)
Journal Article
Herault, D., Aelvoet, K., Blatch, A., Al-Majid, A., Smethurst, C., & Whiting, A. (2007). Benzimidazole nitrogen-directed, regiocontrolled, lithiation of ferrocenyl- and phenyl-N-n-butylbenzimidazoles. Journal of Organic Chemistry, 72(1), 71-75. https://doi.org/10.1021/jo061639%2B2-Ferrocenyl- and 2-phenyl-N-n-butylbenzimidazoles were synthesized to evaluate the influence of the benzimidazole functional group upon their directed lithiation. The regiochemistry of lithiation was studied, as well as the effect of stabilization o... Read More about Benzimidazole nitrogen-directed, regiocontrolled, lithiation of ferrocenyl- and phenyl-N-n-butylbenzimidazoles.
The effects of ring size and substituents on the rates of acid-catalysed hydrolysis of five- and six-membered ring cyclic ketone acetals (2007)
Journal Article
Knowles, J., & Whiting, A. (2007). The effects of ring size and substituents on the rates of acid-catalysed hydrolysis of five- and six-membered ring cyclic ketone acetals. European Journal of Organic Chemistry, 2007(20), 3365-3368. https://doi.org/10.1002/ejoc.200700244A series of sterically similar five- and six-membered ring cyclic diol-derived ketone acetals have been prepared and their rates of acid-catalysed hydrolysis examined. The rates of hydrolysis are substantially affected by acetal ring conformational s... Read More about The effects of ring size and substituents on the rates of acid-catalysed hydrolysis of five- and six-membered ring cyclic ketone acetals.
Mechanistic studies on the Heck-Mizoroki cross-coupling reaction of a hindered vinylboronate ester as a key approach to developing a highly stereoselective synthesis of a Cl-C7 Z,Z,E-triene synthon for viridenomycin (2007)
Journal Article
Batsanov, A., Knowles, J., & Whiting, A. (2007). Mechanistic studies on the Heck-Mizoroki cross-coupling reaction of a hindered vinylboronate ester as a key approach to developing a highly stereoselective synthesis of a Cl-C7 Z,Z,E-triene synthon for viridenomycin. Journal of Organic Chemistry, 72(7), 2525-2532. https://doi.org/10.1021/jo0626010Mechanistic studies of the Heck-Mizoroki reaction of a vinylboronate ester with electronically different (four-substituted) aryl iodides shows that electron donors accelerate the cross-coupling, demonstrating that the oxidative addition step is not r... Read More about Mechanistic studies on the Heck-Mizoroki cross-coupling reaction of a hindered vinylboronate ester as a key approach to developing a highly stereoselective synthesis of a Cl-C7 Z,Z,E-triene synthon for viridenomycin.
Bis(2,6-dimethylpyridyl)iodonium dibromoiodate (2006)
Journal Article
Batsanov, A., Lightfoot, A., Twiddle, S., & Whiting, A. (2006). Bis(2,6-dimethylpyridyl)iodonium dibromoiodate. Acta crystallographica. Section E, E62, o901-o902. https://doi.org/10.1107/s1600536806003680The crystal structure of the title compound, C14H18IN2+·Br2I-, isostructural with the Cl2I analogue, comprises discrete centrosymmetric cations and anions, both with linear coordination of the I atoms.
Synthesis and structure of bifunctional N-alkylbenzimidazole phenylboronate derivatives (2006)
Journal Article
Blatch, A., Chetina, O., Howard, J., Patrick, L., Smethurst, C., & Whiting, A. (2006). Synthesis and structure of bifunctional N-alkylbenzimidazole phenylboronate derivatives. Organic and Biomolecular Chemistry, 4(17), 3297-3302. https://doi.org/10.1039/b607127a
Potassium 4-nitrophenylsulfonate monohydrate. (2006)
Journal Article
Blatch, A., Howard, J., Probert, M., Smethurst, C., & Whiting, A. (2006). Potassium 4-nitrophenylsulfonate monohydrate. Acta crystallographica. Section E, 62(4), m741-m743. https://doi.org/10.1107/s1600536806007835The title compound, K+·C6H4NO5S-·H2O, forms a three-dimensional polymeric structure with an O8 coordination environment of the K+ cation.
N-(diphenylphosphinoyl)hydroxylamine. (2006)
Journal Article
Blatch, A., Howard, J., Probert, M., & Whiting, A. (2006). N-(diphenylphosphinoyl)hydroxylamine. Acta crystallographica. Section E, 62(11), o5343-o5345. https://doi.org/10.1107/s1600536806044862The title compound, C12H12NO2P, is the first structurally studied phosphorus hydroxylamine derivative. The N atom is pyramidal. In the crystal structure, hydrogen bonds link molecules into double ribbons.
tert-Butyl N-(phosphinoyloxy)carbamate. (2006)
Journal Article
Blatch, A., Howard, J., Probert, M., Smethurst, C., & Whiting, A. (2006). tert-Butyl N-(phosphinoyloxy)carbamate. Acta crystallographica. Section E, 62(11), o5346-o5348. https://doi.org/10.1107/s1600536806044783The title compound, C17H20NO4P, contains pyramidal N atoms and adopts similar conformations in its three independent molecules (A, B and C). Molecules A and B form a dimer in the crystal structure by way of a pair of N-H...O hydrogen bonds, as does... Read More about tert-Butyl N-(phosphinoyloxy)carbamate..
Unexpected exothermic reaction between thioacetic acid and DMSO. (2006)
Journal Article
Whiting, A., & Walton, S. (2006). Unexpected exothermic reaction between thioacetic acid and DMSO. Organic Process Research and Development, 10(4), 846-846. https://doi.org/10.1021/op060109c