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Mechanism and optimisation of the homoboroproline bifunctional catalytic asymmetric aldol reaction: Lewis acid tuning through in situ esterification (2012)
Journal Article
Georgiou, I., & Whiting, A. (2012). Mechanism and optimisation of the homoboroproline bifunctional catalytic asymmetric aldol reaction: Lewis acid tuning through in situ esterification. Organic and Biomolecular Chemistry, 10(12), 2422-2430. https://doi.org/10.1039/c2ob06872a

The use of homoboroproline as a bifunctional catalyst in the asymmetric aldol reaction has been investigated mechanistically, particularly with respect to tuning the Lewis acidity of boron by in situ esterification with mildly sigma-electron withdraw... Read More about Mechanism and optimisation of the homoboroproline bifunctional catalytic asymmetric aldol reaction: Lewis acid tuning through in situ esterification.

Asymmetric Direct Amide Synthesis by Kinetic Amine Resolution: A Chiral Bifunctional Aminoboronic Acid Catalyzed Reaction between a Racemic Amine and an Achiral Carboxylic Acid. (2008)
Journal Article
Arnold, K., Davies, B., Hérault, D., & Whiting, A. (2008). Asymmetric Direct Amide Synthesis by Kinetic Amine Resolution: A Chiral Bifunctional Aminoboronic Acid Catalyzed Reaction between a Racemic Amine and an Achiral Carboxylic Acid. Angewandte Chemie International Edition, 47(14), 2673-2676. https://doi.org/10.1002/anie.200705643

Benzimidazole nitrogen-directed, regiocontrolled, lithiation of ferrocenyl- and phenyl-N-n-butylbenzimidazoles (2007)
Journal Article
Herault, D., Aelvoet, K., Blatch, A., Al-Majid, A., Smethurst, C., & Whiting, A. (2007). Benzimidazole nitrogen-directed, regiocontrolled, lithiation of ferrocenyl- and phenyl-N-n-butylbenzimidazoles. Journal of Organic Chemistry, 72(1), 71-75. https://doi.org/10.1021/jo061639%2B

2-Ferrocenyl- and 2-phenyl-N-n-butylbenzimidazoles were synthesized to evaluate the influence of the benzimidazole functional group upon their directed lithiation. The regiochemistry of lithiation was studied, as well as the effect of stabilization o... Read More about Benzimidazole nitrogen-directed, regiocontrolled, lithiation of ferrocenyl- and phenyl-N-n-butylbenzimidazoles.

The effects of ring size and substituents on the rates of acid-catalysed hydrolysis of five- and six-membered ring cyclic ketone acetals (2007)
Journal Article
Knowles, J., & Whiting, A. (2007). The effects of ring size and substituents on the rates of acid-catalysed hydrolysis of five- and six-membered ring cyclic ketone acetals. European Journal of Organic Chemistry, 2007(20), 3365-3368. https://doi.org/10.1002/ejoc.200700244

A series of sterically similar five- and six-membered ring cyclic diol-derived ketone acetals have been prepared and their rates of acid-catalysed hydrolysis examined. The rates of hydrolysis are substantially affected by acetal ring conformational s... Read More about The effects of ring size and substituents on the rates of acid-catalysed hydrolysis of five- and six-membered ring cyclic ketone acetals.

Mechanistic studies on the Heck-Mizoroki cross-coupling reaction of a hindered vinylboronate ester as a key approach to developing a highly stereoselective synthesis of a Cl-C7 Z,Z,E-triene synthon for viridenomycin (2007)
Journal Article
Batsanov, A., Knowles, J., & Whiting, A. (2007). Mechanistic studies on the Heck-Mizoroki cross-coupling reaction of a hindered vinylboronate ester as a key approach to developing a highly stereoselective synthesis of a Cl-C7 Z,Z,E-triene synthon for viridenomycin. Journal of Organic Chemistry, 72(7), 2525-2532. https://doi.org/10.1021/jo0626010

Mechanistic studies of the Heck-Mizoroki reaction of a vinylboronate ester with electronically different (four-substituted) aryl iodides shows that electron donors accelerate the cross-coupling, demonstrating that the oxidative addition step is not r... Read More about Mechanistic studies on the Heck-Mizoroki cross-coupling reaction of a hindered vinylboronate ester as a key approach to developing a highly stereoselective synthesis of a Cl-C7 Z,Z,E-triene synthon for viridenomycin.

Bis(2,6-dimethylpyridyl)iodonium dibromoiodate (2006)
Journal Article
Batsanov, A., Lightfoot, A., Twiddle, S., & Whiting, A. (2006). Bis(2,6-dimethylpyridyl)iodonium dibromoiodate. Acta crystallographica. Section E, E62, o901-o902. https://doi.org/10.1107/s1600536806003680

The crystal structure of the title compound, C14H18IN2+·Br2I-, isostructural with the Cl2I analogue, comprises discrete centrosymmetric cations and anions, both with linear coordination of the I atoms.

N-(diphenylphosphinoyl)hydroxylamine. (2006)
Journal Article
Blatch, A., Howard, J., Probert, M., & Whiting, A. (2006). N-(diphenylphosphinoyl)hydroxylamine. Acta crystallographica. Section E, 62(11), o5343-o5345. https://doi.org/10.1107/s1600536806044862

The title compound, C12H12NO2P, is the first structurally studied phospho­rus hydroxy­lamine derivative. The N atom is pyramidal. In the crystal structure, hydrogen bonds link mol­ecules into double ribbons.

tert-Butyl N-(phosphino­yloxy)carbamate. (2006)
Journal Article
Blatch, A., Howard, J., Probert, M., Smethurst, C., & Whiting, A. (2006). tert-Butyl N-(phosphino­yloxy)carbamate. Acta crystallographica. Section E, 62(11), o5346-o5348. https://doi.org/10.1107/s1600536806044783

The title compound, C17H20NO4P, contains pyramidal N atoms and adopts similar conformations in its three independent mol­ecules (A, B and C). Mol­ecules A and B form a dimer in the crystal structure by way of a pair of N-H...O hydrogen bonds, as does... Read More about tert-Butyl N-(phosphino­yloxy)carbamate..