From human to superhuman: the impact of the microbiome on physiology.

Keely, Stephen J; Cotter, Paul D; Wahlstrom, Annika; Schellekens, Harriët; Weinkove, David; Barrett, Kim E

Abstract

The complex microbial community residing in the human gut has long been understood to regulate gastrointestinal physiology and to participate in digestive diseases, but its extraintestinal actions and influences are increasingly recognized. This article discusses bidirectional interactions between the gut microbiome and athletic performance, metabolism, longevity and the ability of the gut-brain axis to influence cognitive function and mental health.

Citation

Keely, S. J., Cotter, P. D., Wahlstrom, A., Schellekens, H., Weinkove, D., & Barrett, K. E. (2025). From human to superhuman: the impact of the microbiome on physiology. The Journal of Physiology, 603(4), 797-807. https://doi.org/10.1113/JP287883

• Journal Article Type: Article
• Acceptance Date: Jan 2, 2025
• Online Publication Date: Feb 13, 2025
• Publication Date: Feb 15, 2025
• Deposit Date: Feb 18, 2025
• Journal: The Journal of Physiology
• Print ISSN: 0022-3751
• Electronic ISSN: 1469-7793
• Publisher: Wiley
• Peer Reviewed: Peer Reviewed
• Volume: 603
• Issue: 4
• Pages: 797-807
• DOI: https://doi.org/10.1113/JP287883
• Keywords: microbiome, brain–gut axis, longevity, exercise, metabolic disease
• Public URL: https://durham-repository.worktribe.com/output/3474697