Timut Pepper Extract Slows Age-Dependent Decline of Mobility and Collagen Loss and Promotes Longevity.

Jongsma, Elisabeth; Grigolon, Giovanna; Baumann, Julia; Weinkove, David; Ewald, Collin Y; Wandrey, Franziska; Grothe, Torsten

Abstract

Investigations into human longevity are increasingly focusing on healthspan enhancement, not just lifespan extension. Lifestyle modifications and nutritional choices, including food supplements, can significantly affect aging and general health. Phytochemicals in centenarians' diets, such as those found in Timut pepper, a Nepalese spice with various medicinal properties, may contribute to their longevity. Similarly, Sichuan pepper, a related species, has demonstrated anti-inflammatory and neuroprotective activities. With the broader purpose of uncovering a novel treatment to address aging and its comorbidities, this study aims to investigate the potential lifespan- and healthspan-promoting effects of Timut pepper using the model organism We show that Timut pepper extract extends lifespan at different maintenance temperatures and increases the proportion of active nematodes in their early adulthood. In addition, we show that Timut pepper extract enhances speed and distance moved as the nematodes age. Finally, Timut pepper extract assures extracellular matrix homeostasis by slowing the age-dependent decline of collagen expression.

Citation

Jongsma, E., Grigolon, G., Baumann, J., Weinkove, D., Ewald, C. Y., Wandrey, F., & Grothe, T. (2024). Timut Pepper Extract Slows Age-Dependent Decline of Mobility and Collagen Loss and Promotes Longevity. Nutrients, 16(13), Article 2122. https://doi.org/10.3390/nu16132122

• Journal Article Type: Article
• Acceptance Date: Jul 1, 2024
• Online Publication Date: Jul 3, 2024
• Publication Date: Jul 1, 2024
• Deposit Date: Aug 7, 2024
• Publicly Available Date: Aug 7, 2024
• Journal: Nutrients
• Electronic ISSN: 2072-6643
• Publisher: MDPI
• Peer Reviewed: Peer Reviewed
• Volume: 16
• Issue: 13
• Article Number: 2122
• DOI: https://doi.org/10.3390/nu16132122
• Keywords: Collagen - metabolism, Caenorhabditis elegans - drug effects, aging, Longevity - drug effects, Caenorhabditis elegans Proteins - metabolism - genetics, Extracellular Matrix - drug effects - metabolism, speed, extracellular matrix, Plant Extracts - pharmac
• Public URL: https://durham-repository.worktribe.com/output/2617768