Synthesis of metal-binding amino acids

Deck, Katherine E. V.; Brittain, William D. G.

Abstract

The ability for amino acid residues to bind metals underpins the functions of metalloproteins to conduct a plethora of critical processes in living organisms as well as unnatural applications in the fields of catalysis, sensing and medicinal chemistry. The capability to access metal-binding peptides heavily relies on the ability to generate appropriate building blocks. This review outlines recently developed strategies for the synthesis of metal binding non-proteinogenic amino acids. The chemistries to access, as well as to incorporate these amino acids into peptides is presented herein.

Citation

Deck, K. E. V., & Brittain, W. D. G. (online). Synthesis of metal-binding amino acids. Organic and Biomolecular Chemistry, https://doi.org/10.1039/d4ob01326c

• Journal Article Type: Article
• Acceptance Date: Sep 28, 2024
• Online Publication Date: Sep 30, 2024
• Deposit Date: Oct 11, 2024
• Publicly Available Date: Oct 11, 2024
• Journal: Organic & Biomolecular Chemistry
• Print ISSN: 1477-0520
• Electronic ISSN: 1477-0539
• Publisher: Royal Society of Chemistry
• Peer Reviewed: Peer Reviewed
• DOI: https://doi.org/10.1039/d4ob01326c
• Public URL: https://durham-repository.worktribe.com/output/2948189