Selective sensing of lysosomal iron(III) via three-component fluorescence-based strategy in living cells

Biswas, Suprakash; Sharma, Vikas; Kumar, Prashant; Koner, Apurba L.

Abstract

Iron-rich lysosomal compartment causes a significant amount of cellular damage. A lysosome targetable, pH sensitive fluorescent chemosensor based on naphthalimide dye containing a catechol and morpholine moiety has been synthesized, which selectively senses lysosomal Fe(III) with the detection limit of 0.5 ppm. The probe has also been employed for real-time monitoring of lysosomal Fe(III) via live-cell fluorescence imaging.

Citation

Biswas, S., Sharma, V., Kumar, P., & Koner, A. L. (2018). Selective sensing of lysosomal iron(III) via three-component fluorescence-based strategy in living cells. Sensors and Actuators B: Chemical, 260, 460-464. https://doi.org/10.1016/j.snb.2018.01.011

• Journal Article Type: Article
• Acceptance Date: Jan 2, 2018
• Online Publication Date: Jan 9, 2018
• Publication Date: May 1, 2018
• Deposit Date: Jul 10, 2024
• Journal: Sensors and Actuators B: Chemical
• Print ISSN: 0925-4005
• Publisher: Elsevier
• Peer Reviewed: Peer Reviewed
• Volume: 260
• Pages: 460-464
• DOI: https://doi.org/10.1016/j.snb.2018.01.011
• Public URL: https://durham-repository.worktribe.com/output/2523536