Professor Suzanne Fielding suzanne.fielding@durham.ac.uk
Professor
Constitutive model for the rheology of biological tissue
Fielding, Suzanne M.; Cochran, James O.; Huang, Junxiang; Bi, Dapeng; Marchetti, M. Cristina
Authors
James Cochran james.o.cochran@durham.ac.uk
PGR Student Doctor of Philosophy
Junxiang Huang
Dapeng Bi
M. Cristina Marchetti
Abstract
The rheology of biological tissue is key to processes such as embryo development, wound healing, and cancer metastasis. Vertex models of confluent tissue monolayers have uncovered a spontaneous liquid-solid transition tuned by cell shape; and a shear-induced solidification transition of an initially liquidlike tissue. Alongside this jamming/unjamming behavior, biological tissue also displays an inherent viscoelasticity, with a slow time and rate-dependent mechanics. With this motivation, we combine simulations and continuum theory to examine the rheology of the vertex model in nonlinear shear across a full range of shear rates from quastistatic to fast, elucidating its nonlinear stress-strain curves after the inception of shear of finite rate, and its steady state flow curves of stress as a function of strain rate. We formulate a rheological constitutive model that couples cell shape to flow and captures both the tissue solid-liquid transition and its rich linear and nonlinear rheology.
Citation
Fielding, S. M., Cochran, J. O., Huang, J., Bi, D., & Marchetti, M. C. (2023). Constitutive model for the rheology of biological tissue. Physical Review E, 108(4), Article L042602. https://doi.org/10.1103/PhysRevE.108.L042602
Journal Article Type | Article |
---|---|
Acceptance Date | Sep 13, 2023 |
Online Publication Date | Oct 9, 2023 |
Publication Date | 2023-10 |
Deposit Date | Oct 10, 2023 |
Publicly Available Date | Oct 10, 2023 |
Journal | Physical Review E |
Print ISSN | 2470-0045 |
Electronic ISSN | 2470-0053 |
Publisher | American Physical Society |
Peer Reviewed | Peer Reviewed |
Volume | 108 |
Issue | 4 |
Article Number | L042602 |
DOI | https://doi.org/10.1103/PhysRevE.108.L042602 |
Keywords | Wound Healing, Rheology, Motivation, Cell Shape, Embryonic Development |
Public URL | https://durham-repository.worktribe.com/output/1788558 |
Files
Published Journal Article
(537 Kb)
PDF
Licence
http://creativecommons.org/licenses/by/4.0/
Publisher Licence URL
http://creativecommons.org/licenses/by/4.0/
Copyright Statement
Published by the American Physical Society under the terms of the Creative Commons Attribution 4.0 International license. Further distribution of this work must maintain attribution to the author(s) and the published article's title, journal citation, and DOI.
You might also like
Slow Fatigue and Highly Delayed Yielding via Shear Banding in Oscillatory Shear
(2024)
Journal Article
Shear-Driven Solidification and Nonlinear Elasticity in Epithelial Tissues
(2022)
Journal Article
Ductile and Brittle Yielding in Thermal and Athermal Amorphous Materials
(2020)
Journal Article
Simple and effective mechanical cloaking
(2024)
Journal Article
Power law creep and delayed failure of gels and fibrous materials under stress
(2024)
Journal Article
Downloadable Citations
About Durham Research Online (DRO)
Administrator e-mail: dro.admin@durham.ac.uk
This application uses the following open-source libraries:
SheetJS Community Edition
Apache License Version 2.0 (http://www.apache.org/licenses/)
PDF.js
Apache License Version 2.0 (http://www.apache.org/licenses/)
Font Awesome
SIL OFL 1.1 (http://scripts.sil.org/OFL)
MIT License (http://opensource.org/licenses/mit-license.html)
CC BY 3.0 ( http://creativecommons.org/licenses/by/3.0/)
Powered by Worktribe © 2025
Advanced Search