Shear-Driven Solidification and Nonlinear Elasticity in Epithelial Tissues

Huang, Junxiang; Cochran, James O.; Fielding, Suzanne M.; Marchetti, M. Cristina; Bi, Dapeng

Abstract

Biological processes, from morphogenesis to tumor invasion, spontaneously generate shear stresses inside living tissue. The mechanisms that govern the transmission of mechanical forces in epithelia and the collective response of the tissue to bulk shear deformations remain, however, poorly understood. Using a minimal cell-based computational model, we investigate the constitutive relation of confluent tissues under simple shear deformation. We show that an initially undeformed fluidlike tissue acquires finite rigidity above a critical applied strain. This is akin to the shear-driven rigidity observed in other soft matter systems. Interestingly, shear-driven rigidity can be understood by a critical scaling analysis in the vicinity of the second order critical point that governs the liquid-solid transition of the undeformed system. We further show that a solidlike tissue responds linearly only to small strains and but then switches to a nonlinear response at larger stains, with substantial stiffening. Finally, we propose a mean-field formulation for cells under shear that offers a simple physical explanation of shear-driven rigidity and nonlinear response in a tissue.

Citation

Huang, J., Cochran, J. O., Fielding, S. M., Marchetti, M. C., & Bi, D. (2022). Shear-Driven Solidification and Nonlinear Elasticity in Epithelial Tissues. Physical Review Letters, 128(17), https://doi.org/10.1103/physrevlett.128.178001

• Journal Article Type: Article
• Acceptance Date: Mar 31, 2022
• Online Publication Date: Apr 27, 2022
• Publication Date: 2022
• Deposit Date: Jun 29, 2022
• Publicly Available Date: Jun 29, 2022
• Journal: Physical Review Letters
• Print ISSN: 0031-9007
• Electronic ISSN: 1079-7114
• Publisher: American Physical Society
• Peer Reviewed: Peer Reviewed
• Volume: 128
• Issue: 17
• DOI: https://doi.org/10.1103/physrevlett.128.178001
• Public URL: https://durham-repository.worktribe.com/output/1199899