The impact of the sequence-dependent physical properties of DNA on chromain dynamics

Biswas, Aditi; Basu, Aakash

Abstract

The local mechanical properties of DNA depend on local sequence. Here we review recent genomic, structural, and computational efforts at deciphering the “mechanical code”, i.e., the mapping between sequence and mechanics. We then discuss works that suggest how evolution has exploited the mechanical code to control the energetics of DNA-deforming biological processes such as nucleosome organization, transcription factor binding, DNA supercoiling, gene regulation, and 3D chromatin organization. As a whole, these recent
works suggest that DNA sequence in diverse organisms can encode regulatory information governing diverse processes via the mechanical code.

Citation

Biswas, A., & Basu, A. (2023). The impact of the sequence-dependent physical properties of DNA on chromain dynamics. Current Opinion in Structural Biology, 83, Article 102698. https://doi.org/10.1016/j.sbi.2023.102698

• Journal Article Type: Article
• Acceptance Date: Aug 14, 2023
• Online Publication Date: Sep 9, 2023
• Publication Date: 2023-12
• Deposit Date: Sep 19, 2023
• Publicly Available Date: Sep 10, 2024
• Journal: Current Opinion in Structural Biology
• Print ISSN: 0959-440X
• Publisher: Elsevier
• Peer Reviewed: Peer Reviewed
• Volume: 83
• Article Number: 102698
• DOI: https://doi.org/10.1016/j.sbi.2023.102698
• Public URL: https://durham-repository.worktribe.com/output/1742063