Two-year recall for people with no diabetic retinopathy: a multi-ethnic population-based retrospective cohort study using real-world data to quantify the effect

Olvera-Barrios, Abraham; Rudnicka, Alicja R; Anderson, John; Bolter, Louis; Chambers, Ryan; Warwick, Alasdair N; Welikala, Roshan; Fajtl, Jiri; Barman, Sarah; Remagnino, Paolo; Wu, Yue; Lee, Aaron; Chew, Emily Y; Ferris, Frederick L.; Hingorani, Aroon D; Sofat, Reecha; Egan, Catherine; Tufail, Adnan; Owen, Christopher G

Abstract

Background/aims: The English Diabetic Eye Screening Programme (DESP) offers people living with diabetes (PLD) annual screening. Less frequent screening has been advocated among PLD without diabetic retinopathy (DR), but evidence for each ethnic group is limited. We examined the potential effect of biennial versus annual screening on the detection of sight-threatening diabetic retinopathy (STDR) and proliferative diabetic retinopathy (PDR) among PLD without DR from a large urban multi-ethnic English DESP. Methods: PLD in North-East London DESP (January 2012 to December 2021) with no DR on two prior consecutive screening visits with up to 8 years of follow-up were examined. Annual STDR and PDR incidence rates, overall and by ethnicity, were quantified. Delays in identification of STDR and PDR events had 2-year screening intervals been used were determined. Findings: Among 82 782 PLD (37% white, 36% South Asian, and 16% black people), there were 1788 incident STDR cases over mean (SD) 4.3 (2.4) years (STDR rate 0.51, 95% CI 0.47 to 0.55 per 100-person-years). STDR incidence rates per 100-person-years by ethnicity were 0.55 (95% CI 0.48 to 0.62) for South Asian, 0.34 (95% CI 0.29 to 0.40) for white, and 0.77 (95% CI 0.65 to 0.90) for black people. Biennial screening would have delayed diagnosis by 1 year for 56.3% (1007/1788) with STDR and 43.6% (45/103) with PDR. Standardised cumulative rates of delayed STDR per 100 000 persons for each ethnic group were 1904 (95% CI 1683 to 2154) for black people, 1276 (95% CI 1153 to 1412) for South Asian people, and 844 (95% CI 745 to 955) for white people. Interpretation: Biennial screening would have delayed detection of some STDR and PDR by 1 year, especially among those of black ethnic origin, leading to healthcare inequalities.

Citation

Olvera-Barrios, A., Rudnicka, A. R., Anderson, J., Bolter, L., Chambers, R., Warwick, A. N., Welikala, R., Fajtl, J., Barman, S., Remagnino, P., Wu, Y., Lee, A., Chew, E. Y., Ferris, F. L., Hingorani, A. D., Sofat, R., Egan, C., Tufail, A., & Owen, C. G. (2023). Two-year recall for people with no diabetic retinopathy: a multi-ethnic population-based retrospective cohort study using real-world data to quantify the effect. British Journal of Ophthalmology, 107(12), 1839-1845. https://doi.org/10.1136/bjo-2023-324097

• Journal Article Type: Article
• Acceptance Date: Aug 19, 2023
• Online Publication Date: Oct 24, 2023
• Publication Date: 2023-12
• Deposit Date: Sep 5, 2023
• Publicly Available Date: Oct 25, 2023
• Journal: British Journal of Ophthalmology
• Print ISSN: 0007-1161
• Electronic ISSN: 1468-2079
• Publisher: BMJ Publishing Group
• Peer Reviewed: Peer Reviewed
• Volume: 107
• Issue: 12
• Pages: 1839-1845
• DOI: https://doi.org/10.1136/bjo-2023-324097
• Public URL: https://durham-repository.worktribe.com/output/1729581