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Epithelial Stem Cells: Making, Shaping and Breaking the Niche

Ferraces-Riegas, Paula; Galbraith, Anona C.; Doupé, David P.

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Authors

Anona Galbraith anona.c.galbraith@durham.ac.uk
PGR Student Doctor of Philosophy



Abstract

Epithelial stem cells maintain tissues throughout adult life and are tightly regulated by their microenvironmental niche to balance cell production and loss. These stem cells have been studied extensively as signal-receiving cells, responding to cues from other cell types and mechanical stimuli that comprise the niche. However, studies from a wide range of systems have identified epithelial stem cells as major contributors to their own microenvironment either through producing niche cells, acting directly as niche cells or regulating niche cells. The importance of stem cell contributions to the niche is particularly clear in cancer, where tumour cells extensively remodel their microenvironment to promote their survival and proliferation.

Citation

Ferraces-Riegas, P., Galbraith, A. C., & Doupé, D. P. (2022). Epithelial Stem Cells: Making, Shaping and Breaking the Niche. In Advances in Experimental Medicine and Biology. Springer Verlag. https://doi.org/10.1007/5584_2021_686

Online Publication Date Jan 19, 2022
Publication Date 2022
Deposit Date Jan 27, 2022
Publicly Available Date Jan 27, 2022
Publisher Springer Verlag
Series Title Advances in Experimental Medicine and Biology
Book Title Advances in Experimental Medicine and Biology
DOI https://doi.org/10.1007/5584_2021_686
Public URL https://durham-repository.worktribe.com/output/1651625

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http://creativecommons.org/licenses/by/4.0/

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