Dr David Doupe david.p.doupe@durham.ac.uk
Associate Professor
Dr David Doupe david.p.doupe@durham.ac.uk
Associate Professor
O.J Marshall
H. Dayton
A.H. Brand
N. Perrimon
Epithelial homeostasis requires the precise balance of epithelial stem/progenitor proliferation and differentiation. While many signaling pathways that regulate epithelial stem cells have been identified, it is probable that other regulators remain unidentified. Here, we use gene-expression profiling by targeted DamID to identify the stem/progenitor-specific transcription and signaling factors in the Drosophila midgut. Many signaling pathway components, including ligands of most major pathways, exhibit stem/progenitor-specific expression and have regulatory regions bound by both intrinsic and extrinsic transcription factors. In addition to previously identified stem/progenitor-derived ligands, we show that both the insulin-like factor Ilp6 and TNF ligand eiger are specifically expressed in the stem/progenitors and regulate normal tissue homeostasis. We propose that intestinal stem cells not only integrate multiple signals but also contribute to and regulate the homeostatic signaling microenvironmental niche through the expression of autocrine and paracrine factors.
Doupé, D., Marshall, O., Dayton, H., Brand, A., & Perrimon, N. (2018). Drosophila intestinal stem and progenitor cells are major sources and regulators of homeostatic niche signals. Proceedings of the National Academy of Sciences, 115(48), 12218-12223. https://doi.org/10.1073/pnas.1719169115
Journal Article Type | Article |
---|---|
Acceptance Date | Oct 11, 2018 |
Online Publication Date | Nov 7, 2018 |
Publication Date | Nov 7, 2018 |
Deposit Date | Nov 6, 2018 |
Publicly Available Date | Nov 8, 2018 |
Journal | Proceedings of the National Academy of Sciences |
Print ISSN | 0027-8424 |
Electronic ISSN | 1091-6490 |
Publisher | National Academy of Sciences |
Peer Reviewed | Peer Reviewed |
Volume | 115 |
Issue | 48 |
Pages | 12218-12223 |
DOI | https://doi.org/10.1073/pnas.1719169115 |
Public URL | https://durham-repository.worktribe.com/output/1314037 |
Published Journal Article (Final published version)
(1.5 Mb)
PDF
Publisher Licence URL
http://creativecommons.org/licenses/by/4.0/
Copyright Statement
Final published version
Published Journal Article (Advance online version)
(1.5 Mb)
PDF
Publisher Licence URL
http://creativecommons.org/licenses/by/4.0/
Copyright Statement
Advance online version Copyright © 2018 the Author(s). This open access article is distributed under Creative Commons Attribution License 4.0 (CC BY).
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