Dr John Sanderson j.m.sanderson@durham.ac.uk
Associate Professor
The preparation of a series of photoactivatable precursors for use in photoaffinity labelling of potassium channels is described. 3H-Diazirine functionalities were incorporated into the previously described potassium channel antagonists 1-3. The ability to perform enantioselective reductions and Wittig reactions in the presence of 3H-diazirines was central to this work. (c) 2005 Elsevier Ltd. All rights reserved.
Sanderson, J., Findlay, J., & Fishwick, C. (2005). Preparation of Novel 3H-Trifluoromethyldiazirine-Based Photoactivatable Potassium Channel Antagonists. Tetrahedron, 61(47), 11244-11252. https://doi.org/10.1016/j.tet.2005.09.007
Journal Article Type | Article |
---|---|
Publication Date | 2005-11 |
Journal | Tetrahedron |
Print ISSN | 0040-4020 |
Publisher | Elsevier |
Peer Reviewed | Peer Reviewed |
Volume | 61 |
Issue | 47 |
Pages | 11244-11252 |
DOI | https://doi.org/10.1016/j.tet.2005.09.007 |
Keywords | photoreactive; photolabile; antagonist; stereo selective; diazirineHIGHLY STEREOSELECTIVE-SYNTHESIS; ELECTROPLAX SODIUM-CHANNEL;REDUCTION; KETONES |
Public URL | https://durham-repository.worktribe.com/output/1586518 |
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