Preparation of Novel 3H-Trifluoromethyldiazirine-Based Photoactivatable Potassium Channel Antagonists.

Sanderson, J.M.; Findlay, J.B.C.; Fishwick, C.W.G.

Abstract

The preparation of a series of photoactivatable precursors for use in photoaffinity labelling of potassium channels is described. 3H-Diazirine functionalities were incorporated into the previously described potassium channel antagonists 1-3. The ability to perform enantioselective reductions and Wittig reactions in the presence of 3H-diazirines was central to this work. (c) 2005 Elsevier Ltd. All rights reserved.

Citation

Sanderson, J., Findlay, J., & Fishwick, C. (2005). Preparation of Novel 3H-Trifluoromethyldiazirine-Based Photoactivatable Potassium Channel Antagonists. Tetrahedron, 61(47), 11244-11252. https://doi.org/10.1016/j.tet.2005.09.007

• Journal Article Type: Article
• Publication Date: 2005-11
• Journal: Tetrahedron
• Print ISSN: 0040-4020
• Publisher: Elsevier
• Peer Reviewed: Peer Reviewed
• Volume: 61
• Issue: 47
• Pages: 11244-11252
• DOI: https://doi.org/10.1016/j.tet.2005.09.007
• Keywords: photoreactive; photolabile; antagonist; stereo selective; diazirineHIGHLY STEREOSELECTIVE-SYNTHESIS; ELECTROPLAX SODIUM-CHANNEL;REDUCTION; KETONES
• Public URL: https://durham-repository.worktribe.com/output/1586518