A stable, high relaxivity, diaqua gadolinium complex that suppresses anion and protein binding

Messeri, Dimitri; Lowe, Mark P.; Parker, David; Botta, Mauro

Abstract

The high relaxivity of [GdaDO3A](3-) (r(1p) = 12.3 mM(-1) s(- 1), 20 MHz, 298 K, iota (m) = 30 ns) in water is maintained in serum solution because the binding of protein and endogeneous anions, e.g. HCO3-/CO32- is suppressed by electrostatic repulsion.

Citation

Messeri, D., Lowe, M. P., Parker, D., & Botta, M. (2001). A stable, high relaxivity, diaqua gadolinium complex that suppresses anion and protein binding. Chemical Communications, 2742-2743. https://doi.org/10.1039/b108294a

• Journal Article Type: Article
• Acceptance Date: Nov 14, 2001
• Online Publication Date: Dec 6, 2001
• Publication Date: 2001
• Journal: Chemical Communications
• Print ISSN: 1359-7345
• Electronic ISSN: 1364-548X
• Publisher: Royal Society of Chemistry
• Peer Reviewed: Peer Reviewed
• Issue: 24
• Pages: 2742-2743
• DOI: https://doi.org/10.1039/b108294a
• Public URL: https://durham-repository.worktribe.com/output/1579808