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Modelling and experimental analysis of hormonal crosstalk in Arabidopsis

Liu, J.; Mehdi, S.; Topping, J.; Tarkowski, P.; Lindsey, K.

Modelling and experimental analysis of hormonal crosstalk in Arabidopsis Thumbnail


Authors

S. Mehdi

J. Topping

P. Tarkowski



Abstract

An important question in plant biology is how genes influence the crosstalk between hormones to regulate growth. In this study, we model POLARIS (PLS) gene function and crosstalk between auxin, ethylene and cytokinin in Arabidopsis. Experimental evidence suggests that PLS acts on or close to the ethylene receptor ETR1, and a mathematical model describing possible PLS–ethylene pathway interactions is developed, and used to make quantitative predictions about PLS–hormone interactions. Modelling correctly predicts experimental results for the effect of the pls gene mutation on endogenous cytokinin concentration. Modelling also reveals a role for PLS in auxin biosynthesis in addition to a role in auxin transport. The model reproduces available mutants, and with new experimental data provides new insights into how PLS regulates auxin concentration, by controlling the relative contribution of auxin transport and biosynthesis and by integrating auxin, ethylene and cytokinin signalling. Modelling further reveals that a bell-shaped dose–response relationship between endogenous auxin and root length is established via PLS. This combined modelling and experimental analysis provides new insights into the integration of hormonal signals in plants.

Citation

Liu, J., Mehdi, S., Topping, J., Tarkowski, P., & Lindsey, K. (2010). Modelling and experimental analysis of hormonal crosstalk in Arabidopsis. Molecular Systems Biology, 6(1), Article 373. https://doi.org/10.1038/msb.2010.26

Journal Article Type Article
Acceptance Date Apr 7, 2010
Online Publication Date Jun 8, 2010
Publication Date Jun 8, 2010
Deposit Date Jun 6, 2012
Publicly Available Date Jun 8, 2012
Journal Molecular Systems Biology
Publisher EMBO Press
Peer Reviewed Peer Reviewed
Volume 6
Issue 1
Article Number 373
DOI https://doi.org/10.1038/msb.2010.26

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Publisher Licence URL
http://creativecommons.org/licenses/by/4.0/

Copyright Statement
This is an open-access article distributed under the terms of the Creative Commons Attribution Licence, which permits distribution and reproduction in any medium, provided the original author and source are credited. Creation of derivative works is permitted but the resulting work may be distributed only under the same or similar licence to this one. This licence does not permit commercial exploitation without specific permission.






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