Skip to main content

Research Repository

Advanced Search

Delta6-desaturase (FADS2) deficiency unveils the role of omega3- and omega6-polyunsaturated fatty acids

Stoffel, W.; Holz, B.; Jenke, B.; Binczek, E.; Gunter, R.H.; Kiss, C.; Karakesisoglou, I.; Thevis, M.; Weber, A.A.; Arnhold, S.; Addicks, K.


W. Stoffel

B. Holz

B. Jenke

E. Binczek

R.H. Gunter

C. Kiss

M. Thevis

A.A. Weber

S. Arnhold

K. Addicks


Mammalian cell viability is dependent on the supply of the essential fatty acids (EFAs) linoleic and alpha-linolenic acid. EFAs are converted into omega3- and omega6-polyunsaturated fatty acids (PUFAs), which are essential constituents of membrane phospholipids and precursors of eicosanoids, anandamide and docosanoids. Whether EFAs, PUFAs and eicosanoids are essential for cell viability has remained elusive. Here, we show that deletion of delta6-fatty acid desaturase (FADS2) gene expression in the mouse abolishes the initial step in the enzymatic cascade of PUFA synthesis. The lack of PUFAs and eicosanoids does not impair the normal viability and lifespan of male and female fads2 -/- mice, but causes sterility. We further provide the molecular evidence for a pivotal role of PUFA-substituted membrane phospholipids in Sertoli cell polarity and blood-testis barrier, and the gap junction network between granulosa cells of ovarian follicles. The fads2 -/- mouse is an auxotrophic mutant. It is anticipated that FADS2 will become a major focus in membrane, haemostasis, inflammation and atherosclerosis research.


Stoffel, W., Holz, B., Jenke, B., Binczek, E., Gunter, R., Kiss, C., …Addicks, K. (2008). Delta6-desaturase (FADS2) deficiency unveils the role of omega3- and omega6-polyunsaturated fatty acids. The EMBO Journal, 27(17), 2281-2292.

Journal Article Type Article
Publication Date 2008
Journal EMBO Journal
Print ISSN 0261-4189
Electronic ISSN 1460-2075
Publisher EMBO Press
Volume 27
Issue 17
Pages 2281-2292