A CMOS time-resolved fluorescence lifetime analysis micro-system

Rae, Bruce; Muir, Keith R; Gong, Zheng; McKendry, Jonathan; Girkin, John M; Gu, Erdan; Renshaw, David; Dawson, Martin D; Henderson, Robert

Abstract

We describe a CMOS-based micro-system for time-resolved fluorescence lifetime analysis. It comprises a 16 × 4 array of single-photon avalanche diodes (SPADs) fabricated in 0.35 μm high-voltage CMOS technology with in-pixel time-gated photon counting circuitry and a second device incorporating an 8 × 8 AlInGaN blue micro-pixellated light-emitting diode (micro-LED) array bump-bonded to an equivalent array of LED drivers realized in a standard low-voltage 0.35 μm CMOS technology, capable of producing excitation pulses with a width of 777 ps (FWHM). This system replaces instrumentation based on lasers, photomultiplier tubes, bulk optics and discrete electronics with a PC-based micro-system. Demonstrator lifetime measurements of colloidal quantum dot and Rhodamine samples are presented.

Citation

Rae, B., Muir, K. R., Gong, Z., McKendry, J., Girkin, J. M., Gu, E., …Henderson, R. (2009). A CMOS time-resolved fluorescence lifetime analysis micro-system. Sensors, 9(11), 9255-9274. https://doi.org/10.3390/s91109255

• Journal Article Type: Article
• Publication Date: Nov 1, 2009
• Deposit Date: Nov 8, 2011
• Publicly Available Date: Jun 8, 2012
• Journal: Sensors
• Publisher: MDPI
• Peer Reviewed: Peer Reviewed
• Volume: 9
• Issue: 11
• Pages: 9255-9274
• DOI: https://doi.org/10.3390/s91109255
• Public URL: https://durham-repository.worktribe.com/output/1503672