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Synthesis and properties of MIDA boronate containing aromatic amino acids: New peptide building blocks

Colgin, N.; Flinn, T.; Cobb, S.L.

Authors

N. Colgin

T. Flinn



Abstract

Herein, we report the synthesis of novel phenylalanine and tyrosine derivatives containing a N-methyliminodiacetic acid boronate group. These compounds can be prepared enantiomerically pure, they are stable to column chromatography and they can be stored in air for two months without degradation occurring. This new class of boronate containing aromatic amino acids has potential applications in both peptide chemistry and natural product synthesis.

Citation

Colgin, N., Flinn, T., & Cobb, S. (2011). Synthesis and properties of MIDA boronate containing aromatic amino acids: New peptide building blocks. Organic and Biomolecular Chemistry, 9(6), 1864-1870. https://doi.org/10.1039/c0ob00847h

Journal Article Type Article
Publication Date 2011-03
Deposit Date Feb 1, 2012
Journal Organic and Biomolecular Chemistry
Print ISSN 1477-0520
Electronic ISSN 1477-0539
Publisher Royal Society of Chemistry
Peer Reviewed Peer Reviewed
Volume 9
Issue 6
Pages 1864-1870
DOI https://doi.org/10.1039/c0ob00847h