Evaluation of two cyclic di-peptides as inhibitors of CCL2 induced chemotaxis

Saleki, M.; Colgin, N.; Kirby, J.A.; Cobb, S.L.; Ali, S.

Abstract

Monocyte chemoattractant protein (CCL2) plays a major role in the recruitment of monocytes during inflammation. In this study we analysed properties of synthetic CCL2 inhibitors in inhibiting CCL2 mediated monocyte migration. Using trans-endothelial chemotaxis assays compounds C1 and C5 were found to significantly reduce CCL2 mediated migration. Flow based adhesion assays showed reduction in adhesion to VCAM-1 in the presence of 10 nM CCL2 and 50 μM C5 (p < 0.05). Further studies with these compounds can aid in their development as anti-inflammatory therapies.

Citation

Saleki, M., Colgin, N., Kirby, J., Cobb, S., & Ali, S. (2013). Evaluation of two cyclic di-peptides as inhibitors of CCL2 induced chemotaxis. MedChemComm, 4(5), 860-864. https://doi.org/10.1039/c3md00043e

• Journal Article Type: Article
• Publication Date: 2013-05
• Deposit Date: May 15, 2013
• Journal: MedChemComm.
• Print ISSN: 2040-2503
• Electronic ISSN: 2040-2511
• Publisher: Royal Society of Chemistry
• Peer Reviewed: Peer Reviewed
• Volume: 4
• Issue: 5
• Pages: 860-864
• DOI: https://doi.org/10.1039/c3md00043e