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Evaluation of two cyclic di-peptides as inhibitors of CCL2 induced chemotaxis

Saleki, M.; Colgin, N.; Kirby, J.A.; Cobb, S.L.; Ali, S.

Authors

M. Saleki

N. Colgin

J.A. Kirby

S. Ali



Abstract

Monocyte chemoattractant protein (CCL2) plays a major role in the recruitment of monocytes during inflammation. In this study we analysed properties of synthetic CCL2 inhibitors in inhibiting CCL2 mediated monocyte migration. Using trans-endothelial chemotaxis assays compounds C1 and C5 were found to significantly reduce CCL2 mediated migration. Flow based adhesion assays showed reduction in adhesion to VCAM-1 in the presence of 10 nM CCL2 and 50 μM C5 (p < 0.05). Further studies with these compounds can aid in their development as anti-inflammatory therapies.

Citation

Saleki, M., Colgin, N., Kirby, J., Cobb, S., & Ali, S. (2013). Evaluation of two cyclic di-peptides as inhibitors of CCL2 induced chemotaxis. MedChemComm, 4(5), 860-864. https://doi.org/10.1039/c3md00043e

Journal Article Type Article
Publication Date 2013-05
Deposit Date May 15, 2013
Journal MedChemComm.
Print ISSN 2040-2503
Electronic ISSN 2040-2511
Publisher Royal Society of Chemistry
Peer Reviewed Peer Reviewed
Volume 4
Issue 5
Pages 860-864
DOI https://doi.org/10.1039/c3md00043e
Public URL https://durham-repository.worktribe.com/output/1476020