M. Saleki
Evaluation of two cyclic di-peptides as inhibitors of CCL2 induced chemotaxis
Saleki, M.; Colgin, N.; Kirby, J.A.; Cobb, S.L.; Ali, S.
Abstract
Monocyte chemoattractant protein (CCL2) plays a major role in the recruitment of monocytes during inflammation. In this study we analysed properties of synthetic CCL2 inhibitors in inhibiting CCL2 mediated monocyte migration. Using trans-endothelial chemotaxis assays compounds C1 and C5 were found to significantly reduce CCL2 mediated migration. Flow based adhesion assays showed reduction in adhesion to VCAM-1 in the presence of 10 nM CCL2 and 50 μM C5 (p < 0.05). Further studies with these compounds can aid in their development as anti-inflammatory therapies.
Citation
Saleki, M., Colgin, N., Kirby, J., Cobb, S., & Ali, S. (2013). Evaluation of two cyclic di-peptides as inhibitors of CCL2 induced chemotaxis. MedChemComm, 4(5), 860-864. https://doi.org/10.1039/c3md00043e
Journal Article Type | Article |
---|---|
Publication Date | 2013-05 |
Deposit Date | May 15, 2013 |
Journal | MedChemComm. |
Print ISSN | 2040-2503 |
Electronic ISSN | 2040-2511 |
Publisher | Royal Society of Chemistry |
Peer Reviewed | Peer Reviewed |
Volume | 4 |
Issue | 5 |
Pages | 860-864 |
DOI | https://doi.org/10.1039/c3md00043e |
Public URL | https://durham-repository.worktribe.com/output/1476020 |
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