Homozygosity mapping of depressive disorder in a large family from Pakistan: Significant linkage on chromosome 6 and 9†‡
Ayub, M.; Irfan, M.; Maclean, A.; Naeem, F.; Blackwood, D.
A large family with a high prevalence of recurrent major depression and high average inbreeding coefficient was ascertained from rural Pakistan. Subjects were interviewed and diagnosed by a trained psychiatrist, 370 microsatellite markers were genotyped and the program FEstim was used for homozygosity mapping. Significant linkage was found on Chromosome 9 and Chromosome 6 after fine mapping. These regions on Chromosome 6 and 9 may harbor genes which predispose to depression.
Ayub, M., Irfan, M., Maclean, A., Naeem, F., & Blackwood, D. (2013). Homozygosity mapping of depressive disorder in a large family from Pakistan: Significant linkage on chromosome 6 and 9†‡. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, 162(2), 157-162. https://doi.org/10.1002/ajmg.b.32126
|Journal Article Type||Article|
|Publication Date||Mar 1, 2013|
|Deposit Date||Jan 7, 2013|
|Journal||American Journal of Medical Genetics Part B: Neuropsychiatric Genetics|
|Peer Reviewed||Peer Reviewed|
|Keywords||Major depressive disorder, Homozygosity mapping, Pakistan, Genetic linkage.|
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