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Thiazole formation through a modified Gewald reaction

Mallia, C.J.; Englert, L.; Walter, G.C.; Baxendale, I.R.

Thiazole formation through a modified Gewald reaction Thumbnail


C.J. Mallia

L. Englert

G.C. Walter


The synthesis of thiazoles and thiophenes starting from nitriles, via a modified Gewald reaction has been studied for a number of different substrates. 1,4-Dithiane-2,5-diol was used as the aldehyde precursor to give either 2-substituted thiazoles or 2-substituted aminothiophenes depending on the substitution of the α-carbon to the cyano group.


Mallia, C., Englert, L., Walter, G., & Baxendale, I. (2015). Thiazole formation through a modified Gewald reaction. Beilstein Journal of Organic Chemistry, 11, 875-883.

Journal Article Type Article
Acceptance Date Apr 23, 2015
Publication Date May 26, 2015
Deposit Date May 4, 2015
Publicly Available Date Jun 1, 2015
Journal Beilstein Journal of Organic Chemistry
Print ISSN 1860-5397
Publisher Beilstein-Institut
Peer Reviewed Peer Reviewed
Volume 11
Pages 875-883
Keywords Design of experiment (DOE), 1,4-dithiane-2,5-diol, Gewald reaction, Thiazole, Thiophene.
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Copyright Statement
© 2015 Mallia et al; licensee Beilstein-Institut. This is an Open Access article under the terms of the Creative Commons Attribution License (, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
The license is subject to the Beilstein Journal of Organic Chemistry terms and conditions: (

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