Preparation, properties, and antibacterial behavior of a novel cellulose derivative containing lactam groups

Joubert, Fanny; Sharples, Gary J.; Musa, Osama M.; Hodgson, David R.W.; Cameron, Neil R.

Abstract

Lactam groups were introduced onto the backbone of hydroxyethyl cellulose (HEC) to modify properties, such as solubility in organic solvents and solution viscosity and to introduce possible antibacterial activity. Functionalization was achieved using 1-(hydroxymethyl)-2-pyrrolidinone (HMP), and the functionalization reactions were investigated using NMR spectroscopy. The covalent attachment between HEC and HMP was confirmed using 1H-13C correlated NMR experiments. Degrees of functionalization were calculated using integrated 13C NMR spectra, with values of up to 0.9 being demonstrated on the primary alcohol functionality of HEC. The functionalized HECs showed markedly different properties to unfunctionalized HEC, including the ability to swell considerably in water. Functionalized HEC displayed increased thermal stability and reduced solution viscosity compared with unfunctionalized HEC. Moreover, functionalization altered the bacterial adhesion characteristics compared with unfunctionalized HEC.

Citation

Joubert, F., Sharples, G. J., Musa, O. M., Hodgson, D. R., & Cameron, N. R. (2015). Preparation, properties, and antibacterial behavior of a novel cellulose derivative containing lactam groups. Journal of Polymer Science Part A: Polymer Chemistry, 53(1), 68-78. https://doi.org/10.1002/pola.27441

• Journal Article Type: Article
• Acceptance Date: Oct 5, 2014
• Online Publication Date: Oct 29, 2014
• Publication Date: Jan 1, 2015
• Deposit Date: Dec 10, 2014
• Publicly Available Date: Jan 21, 2015
• Journal: Journal of Polymer Science Part A: Polymer Chemistry
• Print ISSN: 0887-624X
• Electronic ISSN: 1099-0518
• Publisher: Wiley
• Peer Reviewed: Peer Reviewed
• Volume: 53
• Issue: 1
• Pages: 68-78
• DOI: https://doi.org/10.1002/pola.27441
• Keywords: Biopolymers, Modification, Polysaccharides, Synthesis.
• Public URL: https://durham-repository.worktribe.com/output/1418440