Expanding the Pyridine–Formic Acid Cocrystal Landscape under Extreme Conditions

Lee, Rachael; Firbank, Andrew J.; Probert, Michael R.; Steed, Jonathan W.

Abstract

Pyridine and formic acid have been crystallized at differing ratios by both cryocrystallization and compression in a diamond anvil cell. Mixtures of the liquids in 1:1, 1:2, and 1:4 ratios all crystallize at high pressure, while only the 1:1 and 1:4 compositions were crystallized by in situ low temperature capillary crystallization. The 1:2 structure crystallized by high pressure is a previously unknown cocrystal of pyridine–formic acid. For the 1:4 mixture, a new polymorph has been identified at a pressure of 14.2 kbar with a distinctly different structure and bonding pattern to that of the previously reported low temperature form.

Citation

Lee, R., Firbank, A. J., Probert, M. R., & Steed, J. W. (2016). Expanding the Pyridine–Formic Acid Cocrystal Landscape under Extreme Conditions. Crystal Growth and Design, 16(7), 4005-4011. https://doi.org/10.1021/acs.cgd.6b00544

• Journal Article Type: Article
• Acceptance Date: May 31, 2016
• Online Publication Date: Jun 1, 2016
• Publication Date: Jul 6, 2016
• Deposit Date: Jun 30, 2016
• Publicly Available Date: Jun 1, 2017
• Journal: Crystal Growth and Design
• Print ISSN: 1528-7483
• Electronic ISSN: 1528-7505
• Publisher: American Chemical Society
• Peer Reviewed: Peer Reviewed
• Volume: 16
• Issue: 7
• Pages: 4005-4011
• DOI: https://doi.org/10.1021/acs.cgd.6b00544