Controlled Flow Precipitation as a Valuable Tool for Synthesis

Filipponi, Paolo; Gioiello, Antimo; Baxendale, Ian R.

Abstract

In most standard flow process, the formation of solids represents a major problem often leading to obstruction of the flow device and reactor shutdown. However, many reactions produce solid products, and therefore finding ways to process these materials is an important area of research. In this article we demonstrate how a dynamically agitated flow reactor can be a powerful tool to facilitate workup and processing of biphasic solid–liquid flow streams at scale.

Citation

Filipponi, P., Gioiello, A., & Baxendale, I. R. (2016). Controlled Flow Precipitation as a Valuable Tool for Synthesis. Organic Process Research and Development, 20(2), 371-375. https://doi.org/10.1021/acs.oprd.5b00331

• Journal Article Type: Article
• Acceptance Date: Oct 17, 2015
• Online Publication Date: Nov 17, 2015
• Publication Date: Feb 19, 2016
• Deposit Date: Nov 20, 2015
• Publicly Available Date: Nov 17, 2016
• Journal: Organic Process Research and Development
• Print ISSN: 1083-6160
• Electronic ISSN: 1520-586X
• Publisher: American Chemical Society
• Peer Reviewed: Peer Reviewed
• Volume: 20
• Issue: 2
• Pages: 371-375
• DOI: https://doi.org/10.1021/acs.oprd.5b00331
• Public URL: https://durham-repository.worktribe.com/output/1397801