Stabilisation of an amorphous form of ROY through a predicted co-former interaction

Corner, Philip A.; Harburn, J. Jonathan; Steed, Jonathan W.; McCabe, James F.; Berry, David J.

Abstract

The highly polymorphic compound ROY, notorious for the colour of its crystals, was the subject of an optimised high-throughput ultrasound-based co-crystal screen. This screen involved a computational pre-screen which highlighted an interaction between ROY and the potential co-former pyrogallol. We have shown that the presence of pyrogallol stabilises the amorphous form of ROY, highlighting the potential for future prediction of co-amorphous behaviours.

Citation

Corner, P. A., Harburn, J. J., Steed, J. W., McCabe, J. F., & Berry, D. J. (2016). Stabilisation of an amorphous form of ROY through a predicted co-former interaction. Chemical Communications, 52(39), 6537-6540. https://doi.org/10.1039/c6cc02949c

• Journal Article Type: Article
• Acceptance Date: Apr 18, 2016
• Online Publication Date: Apr 18, 2016
• Publication Date: May 14, 2016
• Deposit Date: Apr 18, 2016
• Publicly Available Date: Apr 18, 2017
• Journal: Chemical Communications
• Print ISSN: 1359-7345
• Electronic ISSN: 1364-548X
• Publisher: Royal Society of Chemistry
• Peer Reviewed: Peer Reviewed
• Volume: 52
• Issue: 39
• Pages: 6537-6540
• DOI: https://doi.org/10.1039/c6cc02949c
• Public URL: https://durham-repository.worktribe.com/output/1386591