Alvaro Martinez Guimera
Systems modelling ageing: from single senescent cells to simple multi-cellular models
Martinez Guimera, Alvaro; Welsh, Ciaran; Dalle Pezze, Piero; Fullard, Nicola; Nelson, Glyn; Roger, Mathilde F.; Przyborski, Stefan A.; Shanley, Daryl P.
Authors
Ciaran Welsh
Piero Dalle Pezze
Dr Nicola Fullard nicola.fullard@durham.ac.uk
Chief Experimental Officer
Glyn Nelson
Mathilde F. Roger
Professor Stefan Przyborski stefan.przyborski@durham.ac.uk
Deputy Provost
Daryl P. Shanley
Abstract
Systems modelling has been successfully used to investigate several key molecular mechanisms of ageing. Modelling frameworks to allow integration of models and methods to enhance confidence in models are now well established. In this article, we discuss these issues and work through the process of building an integrated model for cellular senescence as a single cell and in a simple tissue context.
Citation
Martinez Guimera, A., Welsh, C., Dalle Pezze, P., Fullard, N., Nelson, G., Roger, M., …Shanley, D. (2017). Systems modelling ageing: from single senescent cells to simple multi-cellular models. Essays in Biochemistry, 61(3), 369-377. https://doi.org/10.1042/ebc20160087
Journal Article Type | Article |
---|---|
Acceptance Date | May 25, 2017 |
Online Publication Date | Jul 11, 2017 |
Publication Date | Jul 11, 2017 |
Deposit Date | Jul 25, 2017 |
Publicly Available Date | Jul 25, 2017 |
Journal | Essays in Biochemistry |
Print ISSN | 0071-1365 |
Electronic ISSN | 1744-1358 |
Publisher | Portland Press |
Peer Reviewed | Peer Reviewed |
Volume | 61 |
Issue | 3 |
Pages | 369-377 |
DOI | https://doi.org/10.1042/ebc20160087 |
Public URL | https://durham-repository.worktribe.com/output/1381193 |
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Copyright Statement
© 2017 The Author(s).
This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY).
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