Sticking and sliding of lipid bilayers on deformable substrates

Stubbington, Liam; Arroyo, Marino; Staykova, Margarita

Abstract

We examine here the properties of lipid bilayers coupled to deformable substrates. We show that by changing the extent of the substrate hydrophilicity, we can control the membrane–substrate coupling and the response of the bilayer to strain deformation. Our results demonstrate that lipid bilayers coupled to flexible substrates can easily accommodate large strains, form stable protrusions and open reversibly pores. These properties, which differ significantly from those of free standing membranes, can extend the applications of the current lipid technologies. Moreover, such systems better capture the mechanical architecture of the cell interface and can provide insights into the capacity of cells to reshape and respond to mechanical perturbations.

Citation

Stubbington, L., Arroyo, M., & Staykova, M. (2016). Sticking and sliding of lipid bilayers on deformable substrates. Soft Matter, 13, 181-186. https://doi.org/10.1039/c6sm00786d

• Journal Article Type: Article
• Acceptance Date: Jun 10, 2016
• Online Publication Date: Jun 13, 2016
• Publication Date: Jun 13, 2016
• Deposit Date: Jun 29, 2016
• Publicly Available Date: Jul 4, 2016
• Journal: Soft Matter
• Print ISSN: 1744-683X
• Electronic ISSN: 1744-6848
• Publisher: Royal Society of Chemistry
• Peer Reviewed: Peer Reviewed
• Volume: 13
• Pages: 181-186
• DOI: https://doi.org/10.1039/c6sm00786d
• Public URL: https://durham-repository.worktribe.com/output/1380281