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Encapsulated bacteria deform lipid vesicles into flagellated swimmers

Le Nagard, Lucas; Brown, Aidan T.; Dawson, Angela; Martinez, Vincent A.; Poon, Wilson C.K.; Staykova, Margarita

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Authors

Lucas Le Nagard

Aidan T. Brown

Angela Dawson

Vincent A. Martinez

Wilson C.K. Poon



Abstract

We study a synthetic system of motile Escherichia coli bacteria encapsulated inside giant lipid vesicles. Forces exerted by the bacteria on the inner side of the membrane are sufficient to extrude membrane tubes filled with one or several bacteria. We show that a physical coupling between the membrane tube and the flagella of the enclosed cells transforms the tube into an effective helical flagellum propelling the vesicle. We develop a simple theoretical model to estimate the propulsive force from the speed of the vesicles and demonstrate the good efficiency of this coupling mechanism. Together, these results point to design principles for conferring motility to synthetic cells.

Citation

Le Nagard, L., Brown, A. T., Dawson, A., Martinez, V. A., Poon, W. C., & Staykova, M. (2022). Encapsulated bacteria deform lipid vesicles into flagellated swimmers. Proceedings of the National Academy of Sciences, 119(34), https://doi.org/10.1073/pnas.2206096119

Journal Article Type Article
Acceptance Date Jul 29, 2022
Online Publication Date Aug 15, 2022
Publication Date 2022
Deposit Date Sep 15, 2022
Publicly Available Date Sep 16, 2022
Journal Proceedings of the National Academy of Sciences
Print ISSN 0027-8424
Electronic ISSN 1091-6490
Publisher National Academy of Sciences
Peer Reviewed Peer Reviewed
Volume 119
Issue 34
DOI https://doi.org/10.1073/pnas.2206096119

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