Lena Kaufmann
Cavity-Containing Supramolecular Gels as a Crystallization Tool for Hydrophobic Pharmaceuticals
Kaufmann, Lena; Kennedy, Stuart R.; Jones, Christopher D.; Steed, Jonathan W.
Authors
Abstract
We present two approaches to low-molecular-weight supramolecular gels bearing hydrophobic cavities based on calixarene-containing building blocks. Gels are formed by a calixarene based tetrahydrazide gelator or a co-gel of a calixarene diammonium salt and a bis-crown ether. The calixarene hydrophobic cavity enables the complexation of hydrophobic drug molecules in a generic fashion thus providing an anchor site on the surface of the gel fibre to inititate drug crystal nucleation and growth. This technique potentially represents a route to growth of hard-to-nucleate polymorphic modifications. The co-gel comprising two components holding together by non-covalent ammonium-crown ether interaction can be easily switched back to the sol state by adding competitive binding cations.
Citation
Kaufmann, L., Kennedy, S. R., Jones, C. D., & Steed, J. W. (2016). Cavity-Containing Supramolecular Gels as a Crystallization Tool for Hydrophobic Pharmaceuticals. Chemical Communications, 52(66), 10113-10116. https://doi.org/10.1039/c6cc04037c
Journal Article Type | Article |
---|---|
Acceptance Date | Jun 29, 2016 |
Online Publication Date | Jun 29, 2016 |
Publication Date | Aug 25, 2016 |
Deposit Date | Jun 30, 2016 |
Publicly Available Date | Jun 30, 2016 |
Journal | Chemical Communications |
Print ISSN | 1359-7345 |
Electronic ISSN | 1364-548X |
Publisher | Royal Society of Chemistry |
Peer Reviewed | Peer Reviewed |
Volume | 52 |
Issue | 66 |
Pages | 10113-10116 |
DOI | https://doi.org/10.1039/c6cc04037c |
Public URL | https://durham-repository.worktribe.com/output/1380177 |
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Copyright Statement
This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
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