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Catalytic Chan–Lam coupling using a ‘tube-in-tube’ reactor to deliver molecular oxygen as an oxidant

Mallia, C.J.; Burton, P.M.; Smith, A.M.R.; Walter, G.C.; Baxendale, I.R.

Catalytic Chan–Lam coupling using a ‘tube-in-tube’ reactor to deliver molecular oxygen as an oxidant Thumbnail


Authors

C.J. Mallia

P.M. Burton

A.M.R. Smith

G.C. Walter



Abstract

A flow system to perform Chan–Lam coupling reactions of various amines and arylboronic acids has been realised employing molecular oxygen as an oxidant for the re-oxidation of the copper catalyst enabling a catalytic process. A tube-in-tube gas reactor has been used to simplify the delivery of the oxygen accelerating the optimisation phase and allowing easy access to elevated pressures. A small exemplification library of heteroaromatic products has been prepared and the process has been shown to be robust over extended reaction times.

Journal Article Type Article
Acceptance Date Jul 13, 2016
Online Publication Date Jul 26, 2016
Publication Date Jul 26, 2016
Deposit Date Aug 9, 2016
Publicly Available Date Aug 9, 2016
Journal Beilstein Journal of Organic Chemistry
Print ISSN 1860-5397
Publisher Beilstein-Institut
Peer Reviewed Peer Reviewed
Volume 12
Pages 1598-1607
DOI https://doi.org/10.3762/bjoc.12.156
Public URL https://durham-repository.worktribe.com/output/1378267

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Published Journal Article (2.2 Mb)
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Publisher Licence URL
http://creativecommons.org/licenses/by/4.0/

Copyright Statement
© 2016 Mallia et al.; licensee Beilstein-Institut.
This is an Open Access article under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
The license is subject to the Beilstein Journal of Organic Chemistry terms and conditions: (http://www.beilstein-journals.org/bjoc)





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