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Bio-prospecting endemic Mascarene Aloes for potential neuroprotectants

Lobine, D.; Howes, M-J.R.; Cummins, I.; Govinden-Soulange, J.; Ranghoo-Sanmukhiya, M.; Lindsey, K.; Chazot, P.L.

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Authors

D. Lobine

M-J.R. Howes

I. Cummins

J. Govinden-Soulange

M. Ranghoo-Sanmukhiya



Abstract

The Mascarene Aloes are used in the traditional pharmacopoeia against various ailments including cutaneous diseases and as antispasmodics. Scientific evidence to support these claims is non-existent and mainly based on the scientific repute of A. vera. The antioxidant profile of methanolic leaf extracts of A. purpurea Lam., A. tormentorii (Marais) L. E. Newton & G. D. Rowley, A. lomatophylloides Balf. f., A. macra Haw. and A. vera (L.) Burm. f. was studied using the total antioxidant capacity, copper equivalent and superoxide dismutase assays. In vitro cytotoxicity was evaluated on CAD (Cath.-a-differentiated) neuronal cells by the methyl tetrazolium assay, and the neuroprotective profile was assessed using hydrogen peroxide-induced neurotoxicity with the CAD cells. The aloin and vitexin content were determined by high-performance liquid chromatography with diode-array detection. A. purpurea had the highest aloin content (546.6 nmol/g), while A. tormentorii had the highest vitexin content (67.3 nmol/g). A. macra (concentration <0.1 mg/mL) elicited a 10% cytotoxicity effect on CAD cells while other Mascarene Aloes were not cytotoxic. This study validates the antioxidant and neuroprotective potential of Mascarene Aloes focusing on their aloin and vitexin content that are also present in other reputed medicinal Aloes.

Citation

Lobine, D., Howes, M., Cummins, I., Govinden-Soulange, J., Ranghoo-Sanmukhiya, M., Lindsey, K., & Chazot, P. (2017). Bio-prospecting endemic Mascarene Aloes for potential neuroprotectants. Phytotherapy Research, 31(12), 1926-1934. https://doi.org/10.1002/ptr.5941

Journal Article Type Article
Acceptance Date Aug 24, 2017
Online Publication Date Oct 11, 2017
Publication Date Dec 1, 2017
Deposit Date Nov 7, 2017
Publicly Available Date Oct 11, 2018
Journal Phytotherapy Research
Print ISSN 0951-418X
Electronic ISSN 1099-1573
Publisher Wiley
Peer Reviewed Peer Reviewed
Volume 31
Issue 12
Pages 1926-1934
DOI https://doi.org/10.1002/ptr.5941
Public URL https://durham-repository.worktribe.com/output/1371836

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Copyright Statement
This is the accepted version of the following article:Lobine, D., Howes, M-J.R., Cummins, I., Govinden-Soulange, J., Ranghoo-Sanmukhiya, M., Lindsey, K. & Chazot, P.L. (2017). Bio-prospecting endemic Mascarene Aloes for potential neuroprotectants, Phytotherapy Research 31(12): 1926-1934, which has been published in final form at https://doi.org/10.1002/ptr.5941. This article may be used for non-commercial purposes in accordance With Wiley Terms and Conditions for self-archiving.






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