Sustainable Flow Synthesis of a Versatile Cyclopentenone Building Block

Baumann, Marcus; Baxendale, Ian R.; Filipponi, Paolo; Hu, Te

doi:10.1021/acs.oprd.7b00328

Sustainable Flow Synthesis of a Versatile Cyclopentenone Building Block

Baumann, Marcus; Baxendale, Ian R.; Filipponi, Paolo; Hu, Te

Authors

Marcus Baumann

Professor Ian Baxendale i.r.baxendale@durham.ac.uk
Professor

Paolo Filipponi

Te Hu

Abstract

A flow based multistep processing sequence to reliably provide the delivery of a highly functional cyclopentenone is described. The exemplification of employing solid dosing of reagents and in-line aqueous extraction has enabled an integrated workflow in a highly automated reactor setup.

Citation

Baumann, M., Baxendale, I. R., Filipponi, P., & Hu, T. (2017). Sustainable Flow Synthesis of a Versatile Cyclopentenone Building Block. Organic Process Research and Development, 21(12), 2052-2059. https://doi.org/10.1021/acs.oprd.7b00328

Journal Article Type	Article
Acceptance Date	Nov 20, 2017
Online Publication Date	Nov 8, 2017
Publication Date	Dec 15, 2017
Deposit Date	Nov 20, 2017
Publicly Available Date	Nov 8, 2018
Journal	Organic Process Research and Development
Print ISSN	1083-6160
Electronic ISSN	1520-586X
Publisher	American Chemical Society
Peer Reviewed	Peer Reviewed
Volume	21
Issue	12
Pages	2052-2059
DOI	https://doi.org/10.1021/acs.oprd.7b00328
Public URL	https://durham-repository.worktribe.com/output/1343558

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Copyright Statement
This document is the Accepted Manuscript version of a Published Work that appeared in final form in Organic Process Research & Development, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see https://doi.org/10.1021/acs.oprd.7b00328.