Melissa Brazier-Hicks
Testing a chemical series inspired by plant stress oxylipin signalling agents for herbicide safening activity
Brazier-Hicks, Melissa; Knight, Kathryn M.; Sellars, Jonathan D.; Steel, Patrick G.; Edwards, Robert
Authors
Kathryn M. Knight
Jonathan D. Sellars
Professor Patrick Steel p.g.steel@durham.ac.uk
Professor
Robert Edwards
Abstract
BACKGROUND Herbicide safening in cereals is linked to a rapid xenobiotic response (XR), involving the induction of glutathione transferases (GSTs). The XR is also invoked by oxidized fatty acids (oxylipins) released during plant stress, suggesting a link between these signalling agents and safening. To examine this relationship, a series of compounds modelled on the oxylipins 12‐oxophytodienoic acid and phytoprostane 1, varying in lipophilicity and electrophilicity, were synthesized. Compounds were then tested for their ability to invoke the XR in Arabidopsis and protect rice seedlings exposed to the herbicide pretilachlor, as compared with the safener fenclorim. RESULTS Of the 21 compounds tested, three invoked the rapid GST induction associated with fenclorim. All compounds possessed two electrophilic carbon centres and a lipophilic group characteristic of both oxylipins and fenclorim. Minor effects observed in protecting rice seedlings from herbicide damage positively correlated with the XR, but did not provide functional safening. CONCLUSION The design of safeners based on the characteristics of oxylipins proved successful in deriving compounds that invoke a rapid XR in Arabidopsis but not in providing classical safening in a cereal. The results further support a link between safener and oxylipin signalling, but also highlight species‐dependent differences in the responses to these compounds.
Citation
Brazier-Hicks, M., Knight, K. M., Sellars, J. D., Steel, P. G., & Edwards, R. (2018). Testing a chemical series inspired by plant stress oxylipin signalling agents for herbicide safening activity. Pest Management Science, 74(4), 828-836. https://doi.org/10.1002/ps.4859
Journal Article Type | Article |
---|---|
Acceptance Date | Jan 9, 2018 |
Online Publication Date | Feb 6, 2018 |
Publication Date | Apr 1, 2018 |
Deposit Date | Mar 19, 2018 |
Publicly Available Date | Mar 19, 2018 |
Journal | Pest Management Science |
Print ISSN | 1526-498X |
Electronic ISSN | 1526-4998 |
Publisher | Wiley |
Peer Reviewed | Peer Reviewed |
Volume | 74 |
Issue | 4 |
Pages | 828-836 |
DOI | https://doi.org/10.1002/ps.4859 |
Files
Published Journal Article
(603 Kb)
PDF
Publisher Licence URL
http://creativecommons.org/licenses/by/4.0/
Copyright Statement
© 2018 The Authors. Pest Management Science published by John Wiley & Sons Ltd on behalf of Society of Chemical Industry.
This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
You might also like
Rational Development of Novel Activity Probes for the Analysis of Human Cytochromes P450
(2016)
Journal Article
The First Intramolecular Silene Diels-Alder Reactions
(2014)
Journal Article
Key role for a glutathione transferase in multiple-herbicide resistance in grass weeds.
(2013)
Journal Article
Downloadable Citations
About Durham Research Online (DRO)
Administrator e-mail: dro.admin@durham.ac.uk
This application uses the following open-source libraries:
SheetJS Community Edition
Apache License Version 2.0 (http://www.apache.org/licenses/)
PDF.js
Apache License Version 2.0 (http://www.apache.org/licenses/)
Font Awesome
SIL OFL 1.1 (http://scripts.sil.org/OFL)
MIT License (http://opensource.org/licenses/mit-license.html)
CC BY 3.0 ( http://creativecommons.org/licenses/by/3.0/)
Powered by Worktribe © 2024
Advanced Search