Synthesis of Antibacterial Nisin–Peptoid Hybrids Using Click Methodology

Bolt, Hannah; Kleijn, Laurens; Martin, Nathaniel; Cobb, Steven

Abstract

Antimicrobial peptides and structurally related peptoids offer potential for the development of new antibiotics. However, progress has been hindered by challenges presented by poor in vivo stability (peptides) or lack of selectivity (peptoids). Herein, we have developed a process to prepare novel hybrid antibacterial agents that combine both linear peptoids (increased in vivo stability compared to peptides) and a nisin fragment (lipid II targeting domain). The hybrid nisin–peptoids prepared were shown to have low micromolar activity (comparable to natural nisin) against methicillin-resistant Staphylococcus aureus.

Citation

Bolt, H., Kleijn, L., Martin, N., & Cobb, S. (2018). Synthesis of Antibacterial Nisin–Peptoid Hybrids Using Click Methodology. Molecules, 23(7), Article 1566. https://doi.org/10.3390/molecules23071566

• Journal Article Type: Article
• Acceptance Date: Jun 21, 2018
• Online Publication Date: Jun 28, 2018
• Publication Date: Jun 28, 2018
• Deposit Date: Jul 12, 2018
• Publicly Available Date: Jul 12, 2018
• Journal: Molecules
• Electronic ISSN: 1420-3049
• Publisher: MDPI
• Peer Reviewed: Peer Reviewed
• Volume: 23
• Issue: 7
• Article Number: 1566
• DOI: https://doi.org/10.3390/molecules23071566
• Public URL: https://durham-repository.worktribe.com/output/1326026