Perspective: Current advances in solid-state NMR spectroscopy

Ashbrook, Sharon E.; Hodgkinson, Paul

Abstract

In contrast to the rapid and revolutionary impact of solution-state Nuclear Magnetic Resonance (NMR) on modern chemistry, the field of solid-state NMR has matured more slowly. This reflects the major technical challenges of much reduced spectral resolution and sensitivity in solid-state as compared to solution-state spectra, as well as the relative complexity of the solid state. In this perspective, we outline the technique developments that have pushed resolution to intrinsic limits and the approaches, including ongoing major developments in the field of Dynamic Nuclear Polarisation, that have enhanced spectral sensitivity. The information on local structure and dynamics that can be obtained using these gains in sensitivity and resolution is illustrated with a diverse range of examples from large biomolecules to energy materials and pharmaceuticals and from both ordered and highly disordered materials. We discuss how parallel developments in quantum chemical calculation, particularly density functional theory, have enabled experimental data to be translated directly into information on local structure and dynamics, giving rise to the developing field of “NMR crystallography.

Citation

Ashbrook, S. E., & Hodgkinson, P. (2018). Perspective: Current advances in solid-state NMR spectroscopy. The Journal of Chemical Physics, 149(4), Article 040901. https://doi.org/10.1063/1.5038547

• Journal Article Type: Article
• Acceptance Date: Jun 1, 2018
• Online Publication Date: Jul 23, 2018
• Publication Date: Jul 23, 2018
• Deposit Date: Aug 9, 2018
• Publicly Available Date: Jul 23, 2019
• Journal: Journal of Chemical Physics
• Print ISSN: 0021-9606
• Electronic ISSN: 1089-7690
• Publisher: American Institute of Physics
• Peer Reviewed: Peer Reviewed
• Volume: 149
• Issue: 4
• Article Number: 040901
• DOI: https://doi.org/10.1063/1.5038547
• Public URL: https://durham-repository.worktribe.com/output/1317911