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Structured ternary fluids as nanocrystal incubators for enhanced crystallization control

Maunder, J.J.; Aguilar, J.A.; Hodgkinson, P.; Cooper, S.J.

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Authors

J.J. Maunder

J.A. Aguilar



Abstract

In crystallization from solution, a ubiquitous process in both industry and the natural world, nucleation is usually the rate-determining step, followed by faster crystal growth. Consequently, crystals typically exist in the nm-size range for such limited times that their investigation and manipulation is hindered. Here, we show that, owing to a degree of restricted diffusion, crystallization in structured ternary fluids can proceed via higher nucleation rate and slower crystal growth pathways. This enables structured ternary fluids to act as nanocrystal incubators, with the nanocrystals existing for extended times. We demonstrate that this generates enhanced crystallization control, with the three ambient pressure polymorphs of glycine, the α-, γ- and β-form, all crystallizing from the octanol/ethanol/water structured ternary fluid, despite the well-known difficulty in crystallizing the slow growing γ-form and the instability of the β-form. The ability of structured ternary fluids to produce notoriously hard to crystallize polymorphs should make them a versatile tool, ideal for polymorph discovery. This may enable a step change in the current, scatter-gun approach to polymorph screening. Furthermore, we show that aliquots of the nanocrystal-containing fluids can successfully seed metastable solutions. Hence, STFs may ultimately help provide a generic methodology for producing crystals and seed suspensions of any desired polymorph to supersede current targeted crystallization and seeding strategies.

Citation

Maunder, J., Aguilar, J., Hodgkinson, P., & Cooper, S. (2022). Structured ternary fluids as nanocrystal incubators for enhanced crystallization control. Chemical Science, 13(44), 13132-13140. https://doi.org/10.1039/d2sc04413g

Journal Article Type Article
Acceptance Date Oct 23, 2022
Online Publication Date Oct 24, 2022
Publication Date Nov 28, 2022
Deposit Date Oct 24, 2022
Publicly Available Date Oct 25, 2022
Journal Chemical Science
Print ISSN 2041-6520
Electronic ISSN 2041-6539
Publisher Royal Society of Chemistry
Peer Reviewed Peer Reviewed
Volume 13
Issue 44
Pages 13132-13140
DOI https://doi.org/10.1039/d2sc04413g

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