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A simple and efficient flow preparation of pyocyanin a virulence factor of Pseudomonas aeruginosa

Mortzfeld, F.; Pietruszka, J.; Baxendale, I.R.

Authors

F. Mortzfeld

J. Pietruszka



Abstract

The synthesis of the naturally occurring toxin pyocyanin has been realized in a short 4 step sequence. The key photochemical reaction and isolation of the final product has been facilitated by the use of flow chemistry techniques and immobilised reagents. Using these procedures gram quantities of pyocyanin were easily prepared in high yield and purity.

Journal Article Type Article
Acceptance Date May 6, 2019
Publication Date Sep 1, 2019
Deposit Date May 7, 2019
Journal European Journal of Organic Chemistry
Print ISSN 1434-193X
Electronic ISSN 1099-0690
Publisher Wiley
Peer Reviewed Peer Reviewed
Volume 2019
Issue 31-32
Pages 5424-5433
DOI https://doi.org/10.1002/ejoc.201900526.
Public URL https://durham-repository.worktribe.com/output/1302579