Recent advances in the development of anti-infective peptoids

Bicker, Kevin L.; Cobb, Steven L

Abstract

In the search for new sources of antimicrobials many researchers have investigated antimicrobial peptides (AMPs) as templates for the design of innovative therapeutics. However, efforts to develop AMPs in this area has been severely hampered by their inherent susceptibility to enzymatic degradation. Given this only a handful of AMPs are currently in clinical trials. Peptide mimetics such as peptoids have emerged as highly promising alternatives to AMPs as they are inherently stable to enzymatic degradation and display potent antimicrobial properties. This feature article highlights the progress that has been made towards the development of novel anti-infective peptoids.

Citation

Bicker, K. L., & Cobb, S. L. (2020). Recent advances in the development of anti-infective peptoids. Chemical Communications, 56(76), 11158-11168. https://doi.org/10.1039/d0cc04704j

• Journal Article Type: Article
• Acceptance Date: Aug 24, 2020
• Online Publication Date: Aug 28, 2020
• Publication Date: 2020-09
• Deposit Date: Oct 14, 2020
• Publicly Available Date: Aug 28, 2021
• Journal: Chemical Communications
• Print ISSN: 1359-7345
• Electronic ISSN: 1364-548X
• Publisher: Royal Society of Chemistry
• Peer Reviewed: Peer Reviewed
• Volume: 56
• Issue: 76
• Pages: 11158-11168
• DOI: https://doi.org/10.1039/d0cc04704j
• Public URL: https://durham-repository.worktribe.com/output/1290197