Hybrid GMP–polyamine hydrogels as new biocompatible materials for drug encapsulation

Lopera, Alberto; Aguilar, Juan A.; Belda, Raquel; Verdejo, Begoña; Steed, Jonathan W.; García-España, Enrique

Abstract

Here we present the preparation and characterization of new biocompatible materials for drug encapsulation. These new gels are based on positively charged [1+1] 1H-pyrazole-based azamacrocycles which minimise the electrostatic repulsions between the negatively charged GMP molecules. Rheological measurements confirm the electroneutral hydrogel structure as the most stable for all the GMP–polyamine systems. Nuclear magnetic resonance (NMR) was employed to investigate the kinetics of the hydrogel formation and cryo-scanning electron microscopy (cryo-SEM) was used to obtain information about the hydrogel morphology, which exhibited a non-homogeneous structure with a high degree of cross-linking. It is possible to introduce isoniazid, which is the most employed antibiotic for tuberculosis treatment, into the hydrogels without disrupting the hydrogel structure at appropriate concentrations for oral administration.

Citation

Lopera, A., Aguilar, J. A., Belda, R., Verdejo, B., Steed, J. W., & García-España, E. (2020). Hybrid GMP–polyamine hydrogels as new biocompatible materials for drug encapsulation. Soft Matter, 16(28), 6514-6522. https://doi.org/10.1039/d0sm00704h

• Journal Article Type: Article
• Acceptance Date: Jun 9, 2020
• Online Publication Date: Jun 10, 2020
• Publication Date: 2020-07
• Deposit Date: Aug 6, 2020
• Publicly Available Date: Jun 9, 2021
• Journal: Soft Matter
• Print ISSN: 1744-683X
• Electronic ISSN: 1744-6848
• Publisher: Royal Society of Chemistry
• Peer Reviewed: Peer Reviewed
• Volume: 16
• Issue: 28
• Pages: 6514-6522
• DOI: https://doi.org/10.1039/d0sm00704h
• Public URL: https://durham-repository.worktribe.com/output/1264302