Carissa M. Lloyd
Current Synthetic Routes to Peptidyl Mono-Fluoromethyl Ketones (FMKs) and Their Applications
Lloyd, Carissa M.; Colgin, Neil; Cobb, Steven L.
Abstract
Peptidyl mono-fluoromethyl ketones (FMKs) are a class of biologically active molecules that show potential as both protease inhibitors for the treatment of a range of diseases and as chemical probes for the interrogation of cellular processes. This review describes the current solid- and solution-phase routes employed for the synthesis of peptidyl mono-FMKs. In addition, it provides a brief overview of some of the key applications of FMKs in the fields of chemical biology and medicinal chemistry.
Citation
Lloyd, C. M., Colgin, N., & Cobb, S. L. (2020). Current Synthetic Routes to Peptidyl Mono-Fluoromethyl Ketones (FMKs) and Their Applications. Molecules, 25(23), Article 5601. https://doi.org/10.3390/molecules25235601
Journal Article Type | Article |
---|---|
Acceptance Date | Nov 24, 2020 |
Online Publication Date | Nov 28, 2020 |
Publication Date | 2020-12 |
Deposit Date | Dec 1, 2020 |
Publicly Available Date | Dec 1, 2020 |
Journal | Molecules |
Electronic ISSN | 1420-3049 |
Publisher | MDPI |
Peer Reviewed | Peer Reviewed |
Volume | 25 |
Issue | 23 |
Article Number | 5601 |
DOI | https://doi.org/10.3390/molecules25235601 |
Public URL | https://durham-repository.worktribe.com/output/1256132 |
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Copyright Statement
© 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access
article distributed under the terms and conditions of the Creative Commons Attribution
(CC BY) license (http://creativecommons.org/licenses/by/4.0/).
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