Andrew T. R. Christy
Control of Superselectivity by Crowding in Three-Dimensional Hosts
Christy, Andrew T. R.; Kusumaatmaja, Halim; Miller, Mark A.
Professor Halim Kusumaatmaja email@example.com
Dr Mark Miller firstname.lastname@example.org
Motivated by the fine compositional control observed in membraneless droplet organelles in cells, we investigate how a sharp binding-unbinding transition can occur between multivalent client molecules and receptors embedded in a porous three-dimensional structure. In contrast to similar superselective binding previously observed at surfaces, we have identified that a key effect in a three-dimensional environment is that the presence of inert crowding agents can significantly enhance or even introduce superselectivity. In essence, molecular crowding initially suppresses binding via an entropic penalty, but the clients can then more easily form many bonds simultaneously. We demonstrate the robustness of the superselective behavior with respect to client valency, linker length, and binding interactions in Monte Carlo simulations of an archetypal lattice polymer model.
Christy, A. T., Kusumaatmaja, H., & Miller, M. A. (2021). Control of Superselectivity by Crowding in Three-Dimensional Hosts. Physical Review Letters, 126(2), Article 028002. https://doi.org/10.1103/physrevlett.126.028002
|Journal Article Type||Article|
|Acceptance Date||Dec 9, 2020|
|Online Publication Date||Jan 11, 2021|
|Publication Date||Jan 15, 2021|
|Deposit Date||Jan 18, 2021|
|Publicly Available Date||Jan 18, 2021|
|Journal||Physical Review Letters|
|Publisher||American Physical Society|
|Peer Reviewed||Peer Reviewed|
Published Journal Article
Reprinted with permission from the American Physical Society: Christy, Andrew T. R., Kusumaatmaja, Halim & Miller, Mark A. (2021). Control of Superselectivity by Crowding in Three-Dimensional Hosts. Physical Review Letters 126(2): 028002 © 2021 by the American Physical Society. Readers may view, browse, and/or download material for temporary copying purposes only, provided these uses are for noncommercial personal purposes. Except as provided by law, this material may not be further reproduced, distributed, transmitted, modified, adapted, performed, displayed, published, or sold in whole or part, without prior written permission from the American Physical Society.
Published Journal Article (Supplementary information.)
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