Carbon Nanotubes: Smart Drug/Gene Delivery Carriers [Corrigendum]

Zare, Hossein; Ahmadi, Sepideh; Ghasemi, Amir; Ghanbari, Mohammad; Rabiee, Navid; Bagherzadeh, Mojtaba; Karimi, Mahdi; Webster, Thomas J; Hamblin, Michael R; Mostafavi, Ebrahim

Abstract

The unique properties of carbon nanotubes (CNTs) (such as their high surface to volume ratios, enhanced conductivity and strength, biocompatibility, ease of functionalization, optical properties, etc.) have led to their consideration to serve as novel drug and gene delivery carriers. CNTs are effectively taken up by many different cell types through several mechanisms. CNTs have acted as carriers of anticancer molecules (including docetaxel (DTX), doxorubicin (DOX), methotrexate (MTX), paclitaxel (PTX), and gemcitabine (GEM)), anti-inflammatory drugs, osteogenic dexamethasone (DEX) steroids, etc. In addition, the unique optical properties of CNTs have led to their use in a number of platforms for improved photo-therapy. Further, the easy surface functionalization of CNTs has prompted their use to deliver different genes, such as plasmid DNA (PDNA), micro-RNA (miRNA), and small interfering RNA (siRNA) as gene delivery vectors for various diseases such as cancers. However, despite all of these promises, the most important continuous concerns raised by scientists reside in CNT nanotoxicology and the environmental effects of CNTs, mostly because of their non-biodegradable state. Despite a lack of widespread FDA approval, CNTs have been studied for decades and plenty of in vivo and in vitro reports have been published, which are reviewed here. Lastly, this review covers the future research necessary for the field of CNT medicine to grow even further.

Citation

Zare, H., Ahmadi, S., Ghasemi, A., Ghanbari, M., Rabiee, N., Bagherzadeh, M., …Mostafavi, E. (2021). Carbon Nanotubes: Smart Drug/Gene Delivery Carriers [Corrigendum]. International Journal of Nanomedicine, Volume 16, https://doi.org/10.2147/ijn.s338281

• Journal Article Type: Article
• Acceptance Date: Sep 8, 2021
• Online Publication Date: Oct 28, 2021
• Publication Date: 2021
• Deposit Date: Jan 25, 2022
• Publicly Available Date: Jan 25, 2022
• Journal: International Journal of Nanomedicine
• Print ISSN: 1176-9114
• Electronic ISSN: 1178-2013
• Publisher: Taylor and Francis Group
• Peer Reviewed: Peer Reviewed
• Volume: Volume 16
• DOI: https://doi.org/10.2147/ijn.s338281