Outputs (185)

Modeling of Intracellular Taurine Levels Associated with Ovarian Cancer Reveals Activation of p53, ERK, mTOR and DNA-Damage-Sensing-Dependent Cell Protection (2024)
Journal Article
Centeno, D., Farsinejad, S., Kochetkova, E., Volpari, T., Gladych-Macioszek, A., Klupczynska-Gabryszak, A., Polotaye, T., Greenberg, M., Kung, D., Hyde, E., Alshehri, S., Pavlovic, T., Sullivan, W., Plewa, S., Vakifahmetoglu-Norberg, H., Monsma, F. J., Muller, P. A. J., Matysiak, J., Zaborowski, M. P., DiFeo, A., …Iwanicki, M. (2024). Modeling of Intracellular Taurine Levels Associated with Ovarian Cancer Reveals Activation of p53, ERK, mTOR and DNA-Damage-Sensing-Dependent Cell Protection. Nutrients, 16(12), Article 1816. https://doi.org/10.3390/nu16121816

Taurine, a non-proteogenic amino acid and commonly used nutritional supplement, can protect various tissues from degeneration associated with the action of the DNA-damaging chemotherapeutic agent cisplatin. Whether and how taurine protects human ovar... Read More about Modeling of Intracellular Taurine Levels Associated with Ovarian Cancer Reveals Activation of p53, ERK, mTOR and DNA-Damage-Sensing-Dependent Cell Protection.

Rapid genotyping of Toxoplasma gondii isolates via Nanopore-based multi-locus sequencing (2024)
Journal Article
Koutsogiannis, Z., & Denny, P. W. (2024). Rapid genotyping of Toxoplasma gondii isolates via Nanopore-based multi-locus sequencing. AMB Express, 14(1), Article 68. https://doi.org/10.1186/s13568-024-01728-x

Toxoplasma gondii is an obligate intracellular parasite associated with severe disease, especially in the immunosuppressed. It is also a cause of congenital malformation and abortion in both animals and humans and is considered one of the most import... Read More about Rapid genotyping of Toxoplasma gondii isolates via Nanopore-based multi-locus sequencing.

Germ fate determinants protect germ precursor cell division by reducing septin and anillin levels at the cell division plane. (2024)
Journal Article
Connors, C. Q., Mauro, M. S., Wiles, J. T., Countryman, A. D., Martin, S. L., Lacroix, B., Shirasu-Hiza, M., Dumont, J., Kasza, K. E., Davies, T. R., & Canman, J. C. (2024). Germ fate determinants protect germ precursor cell division by reducing septin and anillin levels at the cell division plane. Molecular Biology of the Cell, 35(7), Article mbcE24020096T. https://doi.org/10.1091/mbc.E24-02-0096-T

Animal cell cytokinesis, or the physical division of one cell into two, is thought to be driven by constriction of an actomyosin contractile ring at the division plane. The mechanisms underlying cell type-specific differences in cytokinesis remain un... Read More about Germ fate determinants protect germ precursor cell division by reducing septin and anillin levels at the cell division plane..

Global shortfalls in documented actions to conserve biodiversity (2024)
Journal Article
Senior, R. A., Bagwyn, R., Leng, D., Killion, A. K., Jetz, W., & Wilcove, D. S. (2024). Global shortfalls in documented actions to conserve biodiversity. Nature, 630(8016), 387-391. https://doi.org/10.1038/s41586-024-07498-7

Threatened species are by definition species that are in need of assistance. In the absence of suitable conservation interventions, they are likely to disappear soon1. There is limited understanding of how and where conservation interventions are app... Read More about Global shortfalls in documented actions to conserve biodiversity.

Genomic and taxonomic evaluation of 38 Treponema prophage sequences (2024)
Journal Article
Ridgway, R., Lu, H., Blower, T. R., Evans, N. J., & Ainsworth, S. (2024). Genomic and taxonomic evaluation of 38 Treponema prophage sequences. BMC Genomics, 25(1), Article 549. https://doi.org/10.1186/s12864-024-10461-5

Background: Despite Spirochetales being a ubiquitous and medically important order of bacteria infecting both humans and animals, there is extremely limited information regarding their bacteriophages. Of the genus Treponema, there is just a single re... Read More about Genomic and taxonomic evaluation of 38 Treponema prophage sequences.

Alternative protein sources: science powered startups to fuel food innovation (2024)
Journal Article
Lurie-Luke, E. (2024). Alternative protein sources: science powered startups to fuel food innovation. Nature Communications, 15(1), Article 4425. https://doi.org/10.1038/s41467-024-47091-0

Harnessing the potential of considerable food security efforts requires the ability to translate them into commercial applications. This is particularly true for alternative protein sources and startups being on the forefront of innovation represent... Read More about Alternative protein sources: science powered startups to fuel food innovation.

Current understanding of the interplay between extracellular matrix remodelling and gut permeability in health and disease (2024)
Journal Article
Vilardi, A., Przyborski, S., Mobbs, C., Rufini, A., & Tufarelli, C. (2024). Current understanding of the interplay between extracellular matrix remodelling and gut permeability in health and disease. Cell Death Discovery, 10(1), Article 258. https://doi.org/10.1038/s41420-024-02015-1

The intestinal wall represents an interactive network regulated by the intestinal epithelium, extracellular matrix (ECM) and mesenchymal compartment. Under healthy physiological conditions, the epithelium undergoes constant renewal and forms an integ... Read More about Current understanding of the interplay between extracellular matrix remodelling and gut permeability in health and disease.

Inhibition of PDIs Downregulates Core LINC Complex Proteins, Promoting the Invasiveness of MDA-MB-231 Breast Cancer Cells in Confined Spaces In Vitro (2024)
Journal Article
Young, N., Gui, Z., Mustafa, S., Papa, K., Jessop, E., Ruddell, E., …Karakesisoglou, I. (2024). Inhibition of PDIs Downregulates Core LINC Complex Proteins, Promoting the Invasiveness of MDA-MB-231 Breast Cancer Cells in Confined Spaces In Vitro. Cells, 13(11), Article 906. https://doi.org/10.3390/cells13110906

Eukaryotic cells tether the nucleoskeleton to the cytoskeleton via a conserved molecular bridge, called the LINC complex. The core of the LINC complex comprises SUN-domain and KASH-domain proteins that directly associate within the nuclear envelope l... Read More about Inhibition of PDIs Downregulates Core LINC Complex Proteins, Promoting the Invasiveness of MDA-MB-231 Breast Cancer Cells in Confined Spaces In Vitro.

The behaviour of adult Anopheles gambiae, sub-Saharan Africa’s principal malaria vector, and its relevance to malaria control: a review (2024)
Journal Article
Takken, W., Charlwood, D., & Lindsay, S. W. (2024). The behaviour of adult Anopheles gambiae, sub-Saharan Africa’s principal malaria vector, and its relevance to malaria control: a review. Malaria Journal, 23(1), Article 161. https://doi.org/10.1186/s12936-024-04982-3

Background: Mosquitoes of the Anopheles gambiae complex are one of the major vectors of malaria in sub-Saharan Africa. Their ability to transmit this disease of major public health importance is dependent on their abundance, biting behaviour, suscept... Read More about The behaviour of adult Anopheles gambiae, sub-Saharan Africa’s principal malaria vector, and its relevance to malaria control: a review.

Drought response revealed by chromatin organization variation and transcriptional regulation in cotton (2024)
Journal Article
Zhang, B., Long, Y., Pei, L., Huang, X., Li, B., Han, B., …Yang, X. (2024). Drought response revealed by chromatin organization variation and transcriptional regulation in cotton. BMC Biology, 22(1), Article 114. https://doi.org/10.1186/s12915-024-01906-0

Background: Cotton is a major world cash crop and an important source of natural fiber, oil, and protein. Drought stress is becoming a restrictive factor affecting cotton production. To facilitate the development of drought-tolerant cotton varieties,... Read More about Drought response revealed by chromatin organization variation and transcriptional regulation in cotton.