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Current understanding of the interplay between extracellular matrix remodelling and gut permeability in health and disease

Vilardi, Aurora; Przyborski, Stefan; Mobbs, Claire; Rufini, Alessandro; Tufarelli, Cristina

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Authors

Aurora Vilardi

Claire Mobbs claire.l.mobbs@durham.ac.uk
PGR Student Doctor of Philosophy

Alessandro Rufini

Cristina Tufarelli



Abstract

The intestinal wall represents an interactive network regulated by the intestinal epithelium, extracellular matrix (ECM) and mesenchymal compartment. Under healthy physiological conditions, the epithelium undergoes constant renewal and forms an integral and selective barrier. Following damage, the healthy epithelium is restored via a series of signalling pathways that result in remodelling of the scaffolding tissue through finely-regulated proteolysis of the ECM by proteases such as matrix metalloproteinases (MMPs). However, chronic inflammation of the gastrointestinal tract, as occurs in Inflammatory Bowel Disease (IBD), is associated with prolonged disruption of the epithelial barrier and persistent damage to the intestinal mucosa. Increased barrier permeability exhibits distinctive signatures of inflammatory, immunological and ECM components, accompanied by increased ECM proteolytic activity. This narrative review aims to bring together the current knowledge of the interplay between gut barrier, immune and ECM features in health and disease, discussing the role of barrier permeability as a discriminant between homoeostasis and IBD.

Journal Article Type Article
Acceptance Date May 7, 2024
Online Publication Date May 27, 2024
Publication Date May 27, 2024
Deposit Date Jun 12, 2024
Publicly Available Date Jun 12, 2024
Journal Cell Death Discovery
Publisher Springer Nature
Peer Reviewed Peer Reviewed
Volume 10
Issue 1
Article Number 258
DOI https://doi.org/10.1038/s41420-024-02015-1
Public URL https://durham-repository.worktribe.com/output/2471654

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