Current understanding of the interplay between extracellular matrix remodelling and gut permeability in health and disease

Vilardi, Aurora; Przyborski, Stefan; Mobbs, Claire; Rufini, Alessandro; Tufarelli, Cristina

Abstract

The intestinal wall represents an interactive network regulated by the intestinal epithelium, extracellular matrix (ECM) and mesenchymal compartment. Under healthy physiological conditions, the epithelium undergoes constant renewal and forms an integral and selective barrier. Following damage, the healthy epithelium is restored via a series of signalling pathways that result in remodelling of the scaffolding tissue through finely-regulated proteolysis of the ECM by proteases such as matrix metalloproteinases (MMPs). However, chronic inflammation of the gastrointestinal tract, as occurs in Inflammatory Bowel Disease (IBD), is associated with prolonged disruption of the epithelial barrier and persistent damage to the intestinal mucosa. Increased barrier permeability exhibits distinctive signatures of inflammatory, immunological and ECM components, accompanied by increased ECM proteolytic activity. This narrative review aims to bring together the current knowledge of the interplay between gut barrier, immune and ECM features in health and disease, discussing the role of barrier permeability as a discriminant between homoeostasis and IBD.

Citation

Vilardi, A., Przyborski, S., Mobbs, C., Rufini, A., & Tufarelli, C. (2024). Current understanding of the interplay between extracellular matrix remodelling and gut permeability in health and disease. Cell Death Discovery, 10(1), Article 258. https://doi.org/10.1038/s41420-024-02015-1

• Journal Article Type: Article
• Acceptance Date: May 7, 2024
• Online Publication Date: May 27, 2024
• Publication Date: May 27, 2024
• Deposit Date: Jun 12, 2024
• Publicly Available Date: Jun 12, 2024
• Journal: Cell Death Discovery
• Electronic ISSN: 2058-7716
• Publisher: Springer Nature
• Peer Reviewed: Peer Reviewed
• Volume: 10
• Issue: 1
• Article Number: 258
• DOI: https://doi.org/10.1038/s41420-024-02015-1
• Public URL: https://durham-repository.worktribe.com/output/2471654