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Charting the evolutionary path of the SUMO modification system in plants reveals molecular hardwiring of development to stress adaptation (2024)
Journal Article
Ghosh, S., Mellado Sanchez, M., Sue-Ob, K., Roy, D., Jones, A., Blazquez, M. A., & Sadanandom, A. (2024). Charting the evolutionary path of the SUMO modification system in plants reveals molecular hardwiring of development to stress adaptation. The Plant Cell, 36(9), 3131-3144. https://doi.org/10.1093/plcell/koae192

SUMO modification is part of the spectrum of Ubiquitin-like (UBL) systems that give rise to proteoform complexity through post-translational modifications (PTMs). Proteoforms are essential modifiers of cell signaling for plant adaptation to changing... Read More about Charting the evolutionary path of the SUMO modification system in plants reveals molecular hardwiring of development to stress adaptation.

Inheritance of Resistance to Chickpea Fusarium Wilt Disease ( Fusarium oxysporum f. sp. ciceris Race 2) in a Wide-Cross Cicer arietinum × Cicer reticulatum Mapping Family (2024)
Journal Article
Lakmes, A., Jhar, A., Sadanandom, A., Brennan, A. C., & Kahriman, A. (2024). Inheritance of Resistance to Chickpea Fusarium Wilt Disease ( Fusarium oxysporum f. sp. ciceris Race 2) in a Wide-Cross Cicer arietinum × Cicer reticulatum Mapping Family. Genes, 15(6), Article 819. https://doi.org/10.3390/genes15060819

Chickpea (Cicer arietinum) is a major food legume providing high quality nutrition, especially in developing regions. Chickpea wilt (Fusarium oxysporum f. sp. ciceris) causes significant annual losses. Integrated disease management of Fusarium wilt i... Read More about Inheritance of Resistance to Chickpea Fusarium Wilt Disease ( Fusarium oxysporum f. sp. ciceris Race 2) in a Wide-Cross Cicer arietinum × Cicer reticulatum Mapping Family.

SUMO protease FUG1, histone reader AL3 and chromodomain protein LHP1 are integral to repeat expansion-induced gene silencing in Arabidopsis thaliana. (2024)
Journal Article
Sureshkumar, S., Bandaranayake, C., Lv, J., Dent, C. I., Bhagat, P. K., Mukherjee, S., …Balasubramanian, S. (2024). SUMO protease FUG1, histone reader AL3 and chromodomain protein LHP1 are integral to repeat expansion-induced gene silencing in Arabidopsis thaliana. Nature Plants, 10, 749-759. https://doi.org/10.1038/s41477-024-01672-5

Epigenetic gene silencing induced by expanded repeats can cause diverse phenotypes ranging from severe growth defects in plants to genetic diseases such as Friedreich's ataxia in humans. The molecular mechanisms underlying repeat expansion-induced ep... Read More about SUMO protease FUG1, histone reader AL3 and chromodomain protein LHP1 are integral to repeat expansion-induced gene silencing in Arabidopsis thaliana..

SUMOylation of OsPSTOL1 is essential for regulating phosphate starvation responses in rice and Arabidopsis (2024)
Journal Article
Mukkawar, V., Roy, D., Sue-ob, K., Jones, A., Zhang, C., Kumar Bhagat, P., Kakkunnath, S. M., Heuer, S., & Sadanandom, A. (2024). SUMOylation of OsPSTOL1 is essential for regulating phosphate starvation responses in rice and Arabidopsis. Frontiers in Plant Science, 15, Article 1274610. https://doi.org/10.3389/fpls.2024.1274610

Although rice is one of the main sources of calories for most of the world, nearly 60% of rice is grown in soils that are low in phosphorus especially in Asia and Africa. Given the limitations of bioavailable inorganic phosphate (Pi) in soils, it is... Read More about SUMOylation of OsPSTOL1 is essential for regulating phosphate starvation responses in rice and Arabidopsis.

SUMO/deSUMOylation of the BRI1 brassinosteroid receptor modulates plant growth responses to temperature (2023)
Journal Article
Naranjo-Arcos, M., Srivastava, M., Deligne, F., Bhagat, P. K., Mansi, M., Sadanandom, A., & Vert, G. (2023). SUMO/deSUMOylation of the BRI1 brassinosteroid receptor modulates plant growth responses to temperature. Proceedings of the National Academy of Sciences, 120(4), Article 2217255120. https://doi.org/10.1073/pnas.2217255120

Brassinosteroids (BRs) are a class of steroid molecules perceived at the cell surface that act as plant hormones. The BR receptor BRASSINOSTEROID INSENSITIVE1 (BRI1) offers a model to understand receptor-mediated signaling in plants and the role of p... Read More about SUMO/deSUMOylation of the BRI1 brassinosteroid receptor modulates plant growth responses to temperature.

Understanding SUMO-mediated adaptive responses in plants to improve crop productivity (2022)
Journal Article
Clark, L., Sue-Ob, K., Mukkawar, V., Jones, A., & Sadanandom, A. (2022). Understanding SUMO-mediated adaptive responses in plants to improve crop productivity. Essays in Biochemistry, 66(2), 155-168. https://doi.org/10.1042/ebc20210068

The response to abiotic and biotic stresses in plants and crops is considered a multifaceted process. Due to their sessile nature, plants have evolved unique mechanisms to ensure that developmental plasticity remains during their life cycle. Among th... Read More about Understanding SUMO-mediated adaptive responses in plants to improve crop productivity.

The conjugation of SUMO to the transcription factor MYC2 functions in blue light-mediated seedling development in Arabidopsis (2022)
Journal Article
Srivastava, M., Srivastava, A. K., Roy, D., Mansi, M., Gough, C., Bhagat, P. K., Zhang, C., & Sadanandom, A. (2022). The conjugation of SUMO to the transcription factor MYC2 functions in blue light-mediated seedling development in Arabidopsis. The Plant Cell, 34(8), 2892-2906. https://doi.org/10.1093/plcell/koac142

A key function of photoreceptor signaling is the coordinated regulation of a large number of genes to optimize plant growth and development. The basic helix loop helix (bHLH) transcription factor MYC2 is crucial for regulating gene expression in Arab... Read More about The conjugation of SUMO to the transcription factor MYC2 functions in blue light-mediated seedling development in Arabidopsis.

TaWRKY10 transcription factor is a novel Jasmonic Acid signalling regulator involved in immunity against Septoria tritici blotch disease in wheat (2021)
Journal Article
Campanaro, A., Srivastava, A., Zhang, C., Lee, J., Millyard, L., Gatehouse, A., Byrne, E., & Sadanandom, A. (2021). TaWRKY10 transcription factor is a novel Jasmonic Acid signalling regulator involved in immunity against Septoria tritici blotch disease in wheat. Plant Pathology, 70(6), 1397-1408. https://doi.org/10.1111/ppa.13388

Septoria tritici blotch (STB), caused by the fungus Zymoseptoria tritici, is currently the main threat to worldwide wheat production in temperate climates. Understanding the genetic mechanisms that underpin the Z. tritici–wheat interaction will be cr... Read More about TaWRKY10 transcription factor is a novel Jasmonic Acid signalling regulator involved in immunity against Septoria tritici blotch disease in wheat.

SUMO enables substrate selectivity by mitogen-activated protein kinases to regulate immunity in plants (2021)
Journal Article
Verma, V., Srivastava, A. K., Gough, C., Campanaro, A., Srivastava, M., Morrell, R., Joyce, J., Bailey, M., Zhang, C., Krysan, P. J., & Sadanandom, A. (2021). SUMO enables substrate selectivity by mitogen-activated protein kinases to regulate immunity in plants. Proceedings of the National Academy of Sciences, 118(10), Article e2021351118. https://doi.org/10.1073/pnas.2021351118

The versatility of mitogen-activated protein kinases (MAPKs) in translating exogenous and endogenous stimuli into appropriate cellular responses depends on its substrate specificity. In animals, several mechanisms have been proposed about how MAPKs m... Read More about SUMO enables substrate selectivity by mitogen-activated protein kinases to regulate immunity in plants.