Glutamatergic dysfunction leads to a hyper-dopaminergic phenotype through deficits in short-term habituation: a mechanism for aberrant salience
(2022)
Journal Article
Panayi, M. C., Boerner, T., Jahans-Price, T., Huber, A., Sprengel, R., Gilmour, G., …Bannerman, D. M. (2022). Glutamatergic dysfunction leads to a hyper-dopaminergic phenotype through deficits in short-term habituation: a mechanism for aberrant salience. Molecular Psychiatry, 28(2023), 579-587. https://doi.org/10.1038/s41380-022-01861-8
Psychosis in disorders like schizophrenia is commonly associated with aberrant salience and elevated striatal dopamine. However, the underlying cause(s) of this hyper-dopaminergic state remain elusive. Various lines of evidence point to glutamatergic... Read More about Glutamatergic dysfunction leads to a hyper-dopaminergic phenotype through deficits in short-term habituation: a mechanism for aberrant salience.