Outputs (4)

A biphasic reduction in a measure of palatability following sucrose consumption in mice (2017)
Journal Article
Strickland, J. A., Austen, J. M., & Sanderson, D. J. (2018). A biphasic reduction in a measure of palatability following sucrose consumption in mice. Physiology & Behavior, 184, 129-134. https://doi.org/10.1016/j.physbeh.2017.11.019

Consumption of foods results in a transient reduction in hedonic value that influences the extent and nature of feeding behavior. The time course of this effect, however, is poorly specified. In an initial experiment, using an analysis of the microst... Read More about A biphasic reduction in a measure of palatability following sucrose consumption in mice.

GluA1 AMPAR subunit deletion reduces the hedonic response to sucrose but leaves satiety and conditioned responses intact (2017)
Journal Article
Austen, J. M., Sprengel, R., & Sanderson, D. J. (2017). GluA1 AMPAR subunit deletion reduces the hedonic response to sucrose but leaves satiety and conditioned responses intact. Scientific Reports, 7(1), Article 7424. https://doi.org/10.1038/s41598-017-07542-9

The GluA1 subunit of the AMPA receptor has been implicated in schizophrenia. While GluA1 is important for cognition, it is not clear what the role of GluA1 is in hedonic responses that are relevant to the negative symptoms of disorders such as schizo... Read More about GluA1 AMPAR subunit deletion reduces the hedonic response to sucrose but leaves satiety and conditioned responses intact.

Altered balance of excitatory and inhibitory learning in a genetically modified mouse model of glutamatergic dysfunction relevant to schizophrenia (2017)
Journal Article
Sanderson, D. J., Lee, A., Sprengel, R., Seeburg, P. H., Harrison, P. J., & Bannerman, D. M. (2017). Altered balance of excitatory and inhibitory learning in a genetically modified mouse model of glutamatergic dysfunction relevant to schizophrenia. Scientific Reports, 7(1), Article 1765. https://doi.org/10.1038/s41598-017-01925-8

The GluA1 AMPAR subunit (encoded by the Gria1 gene) has been implicated in schizophrenia. Gria1 knockout in mice results in recently experienced stimuli acquiring aberrantly high salience. This suggests that GluA1 may be important for learning that i... Read More about Altered balance of excitatory and inhibitory learning in a genetically modified mouse model of glutamatergic dysfunction relevant to schizophrenia.

The group II metabotropic glutamate receptor agonist LY354740 and the D2 receptor antagonist haloperidol reduce locomotor hyperactivity but fail to rescue spatial working memory in GluA1 knockout mice (2017)
Journal Article
Boerner, T., Bygrave, A., Chen, J., Fernando, A., Jackson, S., Barkus, C., …Sanderson, D. J. (2017). The group II metabotropic glutamate receptor agonist LY354740 and the D2 receptor antagonist haloperidol reduce locomotor hyperactivity but fail to rescue spatial working memory in GluA1 knockout mice. European Journal of Neuroscience, 45(7), 912-921. https://doi.org/10.1111/ejn.13539

Group II metabotropic glutamate receptor agonists have been suggested as potential anti-psychotics, at least in part, based on the observation that the agonist LY354740 appeared to rescue the cognitive deficits caused by non-competitive N-methyl-D-as... Read More about The group II metabotropic glutamate receptor agonist LY354740 and the D2 receptor antagonist haloperidol reduce locomotor hyperactivity but fail to rescue spatial working memory in GluA1 knockout mice.