Outputs (26)

Mice integrate conspecific and contextual information in forming social episodic-like memories under spontaneous recognition task conditions (2024)
Journal Article
Ross, T. W., Poulter, S. L., Lever, C., & Easton, A. (in press). Mice integrate conspecific and contextual information in forming social episodic-like memories under spontaneous recognition task conditions. Scientific Reports,

The ability to remember unique past events (episodic memory) may be an evolutionarily conserved function, with accumulating evidence of episodic-(like) memory processing in rodents. In humans, it likely contributes to successful complex social networ... Read More about Mice integrate conspecific and contextual information in forming social episodic-like memories under spontaneous recognition task conditions.

Frequency matters: how changes in hippocampal theta frequency can influence temporal coding, anxiety-reduction, and memory (2023)
Journal Article
Hines, M., Poulter, S., Douchamps, V., Pibiri, F., McGregor, A., & Lever, C. (2023). Frequency matters: how changes in hippocampal theta frequency can influence temporal coding, anxiety-reduction, and memory. Frontiers in Systems Neuroscience, 16, https://doi.org/10.3389/fnsys.2022.998116

Hippocampal theta frequency is a somewhat neglected topic relative to theta power, phase, coherence, and cross-frequency coupling. Accordingly, here we review and present new data on variation in hippocampal theta frequency, focusing on functional as... Read More about Frequency matters: how changes in hippocampal theta frequency can influence temporal coding, anxiety-reduction, and memory.

Vector trace cells in the subiculum of the hippocampal formation (2020)
Journal Article
Poulter, S., Lee, S. A., Dachtler, J., Wills, T. J., & Lever, C. (2021). Vector trace cells in the subiculum of the hippocampal formation. Nature Neuroscience, 24, 266-275. https://doi.org/10.1038/s41593-020-00761-w

Successfully navigating in physical or semantic space requires a neural representation of allocentric (map-based) vectors to boundaries, objects and goals. Cognitive processes such as path-planning and imagination entail the recall of vector represen... Read More about Vector trace cells in the subiculum of the hippocampal formation.

Distinct and combined responses to environmental geometry and features in a working-memory reorientation task in rats and chicks (2020)
Journal Article
Lee, S. A., Austen, J. M., Sovrano, V. A., Vallortigara, G., McGregor, A., & Lever, C. (2020). Distinct and combined responses to environmental geometry and features in a working-memory reorientation task in rats and chicks. Scientific Reports, 10(1), Article 7508. https://doi.org/10.1038/s41598-020-64366-w

The original provocative formulation of the ‘geometric module’ hypothesis was based on a working-memory task in rats which suggested that spontaneous reorientation behavior is based solely on the environmental geometry and is impervious to featural c... Read More about Distinct and combined responses to environmental geometry and features in a working-memory reorientation task in rats and chicks.

En route to delineating hippocampal roles in spatial learning (2019)
Journal Article
Poulter, S., Austen, J. M., Kosaki, Y., Dachtler, J., Lever, C., & McGregor, A. (2019). En route to delineating hippocampal roles in spatial learning. Behavioural Brain Research, 369, Article 111936. https://doi.org/10.1016/j.bbr.2019.111936

The precise role played by the hippocampus in spatial learning tasks, such as the Morris Water Maze (MWM), is not fully understood. One theory is that the hippocampus is not required for ‘knowing where’ but rather is crucial in ‘getting there’. To ex... Read More about En route to delineating hippocampal roles in spatial learning.

The neurobiology of mammalian navigation (2018)
Journal Article
Poulter, S., Hartley, T., & Lever, C. (2018). The neurobiology of mammalian navigation. Current Biology, 28(17), R1023-R1042. https://doi.org/10.1016/j.cub.2018.05.050

Mammals have evolved specialized brain systems to support efficient navigation within diverse habitats and over varied distances, but while navigational strategies and sensory mechanisms vary across species, core spatial components appear to be widel... Read More about The neurobiology of mammalian navigation.

Hippocampal CA1 activity correlated with the distance to the goal and navigation performance (2017)
Journal Article
Spiers, H. J., Olafsdottir, H. F., & Lever, C. (2018). Hippocampal CA1 activity correlated with the distance to the goal and navigation performance. Hippocampus, 28(9), 644-658. https://doi.org/10.1002/hipo.22813

Coding the distance to a future goal is an important function of a neural system supporting navigation. While some evidence indicates the hippocampus increases activity with proximity to the goal, others have found activity to decrease with proximity... Read More about Hippocampal CA1 activity correlated with the distance to the goal and navigation performance.

Reconciling the different faces of hippocampal theta: The role of theta oscillations in cognitive, emotional and innate behaviors (2017)
Journal Article
Korotkova, T., Ponomarenko, A., Monaghan, C. K., Poulter, S. L., Cacucci, F., Wills, T., …Lever, C. (2017). Reconciling the different faces of hippocampal theta: The role of theta oscillations in cognitive, emotional and innate behaviors. Neuroscience & Biobehavioral Reviews, 85, 65-80. https://doi.org/10.1016/j.neubiorev.2017.09.004

The theta oscillation (5–10 Hz) is a prominent behavior-specific brain rhythm. This review summarizes studies showing the multifaceted role of theta rhythm in cognitive functions, including spatial coding, time coding and memory, exploratory locomoti... Read More about Reconciling the different faces of hippocampal theta: The role of theta oscillations in cognitive, emotional and innate behaviors.

Allocentric Spatial Memory Testing Predicts Conversion from Mild Cognitive Impairment to Dementia: An Initial Proof-of-Concept Study (2016)
Journal Article
Wood, R., Moodley, K., Lever, C., Minati, L., & Chan, D. (2016). Allocentric Spatial Memory Testing Predicts Conversion from Mild Cognitive Impairment to Dementia: An Initial Proof-of-Concept Study. Frontiers in Neurology, 7, Article 215. https://doi.org/10.3389/fneur.2016.00215

The hippocampus is one of the first regions to exhibit neurodegeneration in Alzheimer’s disease (AD), and knowledge of its role in allocentric spatial memory may therefore aid early diagnosis of AD. The 4 Mountains Test (4MT) is a short and easily ad... Read More about Allocentric Spatial Memory Testing Predicts Conversion from Mild Cognitive Impairment to Dementia: An Initial Proof-of-Concept Study.

Heterozygous deletion of α-neurexin I or α-neurexin II results in behaviors relevant to autism and schizophrenia (2015)
Journal Article
Dachtler, J., Ivorra, J., Rowland, T., Lever, C., Rodgers, R., & Clapcote, S. (2015). Heterozygous deletion of α-neurexin I or α-neurexin II results in behaviors relevant to autism and schizophrenia. Behavioral Neuroscience, 129(6), 765-776. https://doi.org/10.1037/bne0000108

The neurexins are a family of presynaptic cell adhesion molecules. Human genetic studies have found heterozygous deletions affecting NRXN1 and NRXN2, encoding α-neurexin I (Nrxn1α) and α-neurexin II (Nrxn2α), in individuals with autism spectrum disor... Read More about Heterozygous deletion of α-neurexin I or α-neurexin II results in behaviors relevant to autism and schizophrenia.