An evolutionarily conserved coiled-coil protein implicated in polycystic kidney disease is involved in basal body duplication and flagellar biogenesis in Trypanosoma brucei (2005)
Journal Article
Morgan, G., Denny, P., Vaughan, S., Goulding, D., Jeffries, T., Smith, D., …Field, M. (2005). An evolutionarily conserved coiled-coil protein implicated in polycystic kidney disease is involved in basal body duplication and flagellar biogenesis in Trypanosoma brucei. Molecular and Cellular Biology, 25(9), 3774-3783. https://doi.org/10.1128/mcb.25.9.3774-3783.2005

Trypanosoma brucei is a flagellated protozoan with a highly polarized cellular structure. TbLRTP is a trypanosomal protein containing multiple SDS22-class leucine-rich repeats and a coiled-coil domain with high similarity to a mammalian testis-specif... Read More about An evolutionarily conserved coiled-coil protein implicated in polycystic kidney disease is involved in basal body duplication and flagellar biogenesis in Trypanosoma brucei.

Direct transport across the plasma membrane of mammalian cells of Leishmania HASPB as revealed by a CHO export mutant (2005)
Journal Article
Stegmayer, C., Kehlenbach, A., Tournaviti, S., Wegehingel, S., Zehe, C., Denny, P., …Nickel, W. (2005). Direct transport across the plasma membrane of mammalian cells of Leishmania HASPB as revealed by a CHO export mutant. Journal of Cell Science, 118(3), 517-527. https://doi.org/10.1242/jcs.01645

Leishmania HASPB is a lipoprotein that is exported to the extracellular space from both Leishmania parasites and mammalian cells via an unconventional secretory pathway. Exported HASPB remains anchored in the outer leaflet of the plasma membrane medi... Read More about Direct transport across the plasma membrane of mammalian cells of Leishmania HASPB as revealed by a CHO export mutant.

Leishmania major: clathrin and adaptin complexes of an intra-cellular parasite (2005)
Journal Article
Denny, P., Morgan, G., Field, M., & Smith, D. (2005). Leishmania major: clathrin and adaptin complexes of an intra-cellular parasite. Experimental Parasitology, 109(1), 33-37. https://doi.org/10.1016/j.exppara.2004.10.007

To investigate the role of clathrin-mediated trafficking during the Leishmania lifecycle, open reading frames encoding clathrin heavy chain and the β-adaptins, major components of the adaptor complexes, have been analysed both in silico and experimen... Read More about Leishmania major: clathrin and adaptin complexes of an intra-cellular parasite.